Bristol-myers Squibb Compnay

Kevin R Webster

S David Kimball

Raj N Misra

David Brent Rawlins

Kyoung S Kim

Michael A Poss

Wen-Ching Han

John T Hunt

Zhen-wei Cai

David K Bol

Isia Bursuker

Kevin G Coleman

Vikas Goel

Carbon substituted aminothiazole inhibitors of cyclin dependent kinases

Methods for preventing and treating alopecia induced by chemotherapy or radiotherapy

Aminothiazole inhibitors of cyclin dependent kinases

Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof for use as inhibitors of cyclin dependent kinases, wherein:

Use of pyrazolo [3,4-b] pyridine as cyclin dependent kinase inhibitors

Compounds of the formula ##STR1## and pharmaceuticaly acceptable salts thereof. As used in formula I, and throughout the specification, the symbols have the following meanings:

Novel peptide and peptide mimetic ligands which act as inhibitors of p34.sup.cdc2 kinase, p33.sup.cdk2 kinase and human papillomavirus transforming protein E7 (HPV E7) are disclosed. The inhibitors are derived from the binding domains of a retinoblastoma tumor suppressor protein (Rb), p107 and a cyclin.

Peptide inhibitors of the p33.sup.cdk2 and p34.sup.cdc2 cell cycle

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Yardley, PA, United States of America

Kevin R Webster