Micromass UK Limited

Micromss UK Limited

Kevin R Howes

Jason Lee Wildgoose

Martin Raymond Green

Steven Derek Pringle

Paul Anthony Read

Richard Barrington Moulds

Ian David Trivett

Eliot Powell

A method of mass and/or ion mobility spectrometry is disclosed that comprises accumulating ions for a first period of time (T) one or more times so as to form one or more first groups of ions, accumulating ions for a second period of time (T) one or more times so as to form one or more second groups of ions, wherein the second period of time (T) is less that the first period of time (T), analysing the one or more first groups of ions to generate one or more first data sets, analysing the one or more second groups of ions to generate one or more second data sets, and determining whether the one or more first data sets comprise saturated and/or distorted data. If it is determined that the one or more first data sets comprise saturated and/or distorted data, then the method further comprises replacing the saturated and/or distorted data from the one or more first data sets with corresponding data from the one or more second data sets.

Trap fill time dynamic range enhancment

Trap fill time dynamic range enhancement

A detachable and replaceable ion source for a mass spectrometer. The ion source comprises a housing which defines an ion source chamber, an ion source mounting means complementary to mounting means on the mass spectrometer to detachably couple with the mass spectrometer. This allows movement of the housing to bring the ion source chamber into a position of use at the inlet of said mass spectrometer and to take the ion source chamber from said position of use into a retracted position. Sealing means is provided to create an air tight seal between the housing and the mass spectrometer when the ion source chamber is in its position of use. A release mechanism is provided which cooperates with the mass spectrometer to allow the said movement of said housing.

Mass spectrometer

An ion source, a mass spectrometer and a method of enhancing the performance of an ion source for use with a mass spectrometer. The ion source has a housing incorporating an ion source enclosure defining a chamber and an outer cover remote from the chamber. A fluid flow passageway is provided between the ion source enclosure and the outer cover. The method of the invention comprising supplying to the ion source housing a regulated flow of fluid through the fluid passageways so as to maintain the ion source enclosure within a predetermined temperature range of substantially between 60&#xb0; c. and 80&#xb0; c. and preferably at 70&#xb0; c.

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Altrincham, United Kingdom

Kevin R Howes