Lonza Inc.

Other

Kansas State University Research Foundation

Oklahoma State University

Kevin Q Owen

Jim L Nelssen

Robert D Goodband

Ulla Freitas

Bryan Rodriguez

Jay Udani

Michael D Tokach

Stephen A Blum

Robert G Teeter

Jason C Woodworth

Rene A Blum

Robert E Musser

Stanley L Vanhooser

Kathy L Gross

Mike D Tokach

Sung I Koo

Steve S Dritz

Frauke Warrikoff

Daryl Real

George Collings

Craig Coon

Johnny Lopez

Richard Sasse

Patrick R O'Quinn

Adriana Williams

Uiia Freitas

The invention relates to the use of L-carnitine, a salt of L-carnitine, a derivative of L-carnitine and/or salt of a derivative of L-carnitine, as well as respective methods and compositions, for reducing or preventing fatigue and/or for improving cognitive function in an animal. The animal is preferably a healthy individual and the use is preferably a non-therapeutic use.

Use of L-carnitine, salts and derivatives thereof for reducing or preventing fatigue and improving cognitive function

A method for reducing muscle damage and/or oxidative stress in active mammals as disclosed. In one embodiment, the mammals are administered a carnitine supplement. The L-carnitine supplement may be administered without any other pharmaceutical or drug products. After physical activity the L-carnitine supplement can lower myoglobin, TBARS, and creatine kinase in the bloodstream.

Method for decreasing skeletal muscle damage and/or oxidative stress in mammals

The present invention discloses a composition containing Arabinogalactan for enhancing the adaptive immune response in subjects to foreign antigen(s) by administering said composition prior, during and after the phase of exposure to said foreign antigen(s). Furthermore, the present invention relates to a vaccination kit comprising a composition comprising Arabinogalactan and a vaccine.

Arabinogalactan for enhancing the adaptive immune response

The present invention relates to supplementing the diets to sows during the periods of gestation, lactation, and breeding by feeding L-carnitine and chromium. The supplementation enhances pork productivity by increasing the number of pigs born alive in the subsequent reproductive cycle. Sow diets of this invention include L-carnitine and L-carnitine salts and trivalent chromium salts, such as chromium picolinate and chromium nicotinate. L-Carnitine is generally added to the swine feed formulation in the amount of from about 20 to about 1500 ppm, and the trivalent chromium salt is generally added to the swine feed formulation in the amount of from about 20 ppb to about 1000 ppb. The invention also relates to supplemented sow diets and feed supplement formulation.

Method of enhancing reproductive performance in sows

An effective amount of carnitine is administered to broiler type poultry to prevent or alleviate ascites. In the preferred embodiment, a carnitine supplemented diet is fed to broiler type chickens in a feed composition during the phase of rapid tissue accretion where a high oxygen requirement stresses the birds' cardiovascular support system. The feed composition preferably contains between 5 and 1000 ppm of carnitine.

Carnitine supplemented diet to prevent or alleviate ascites in broiler type poultry

The present invention provides a method for increasing the intestinal (lymphatic) absorption, cellular concentration, biliary secretion, hepatic storage, and/or liver concentration of a fat soluble vitamin in a post-menopausal woman. The method comprises orally administering to a post-menopausal woman in need thereof, a fat soluble vitamin and a fat soluble vitamin absorption increasing effective amount of L-carnitine. The L-carnitine enhances the antioxidant defense mechanism and lowers the risk of certain degenerative diseases, such as coronary heart disease, age-related macular degeneration, osteoporosis, cancer, and Alzheimer's, in post-menopausal women. The invention also provides a method for increasing the intestinal absorption of a fat soluble vitamin in an animal. The method comprises orally administering to the animal in need thereof, a fat soluble vitamin and a fat soluble vitamin absorption increasing effective amount of L-carnitine.

Method for increasing intestinal absorption of fat soluble vitamins in post-menopausal women and lower animals

The present invention relates to a method of feeding carnitine supplemented diets to sows during the period of gestation or during both gestation and lactation periods. The method enhances pork productivity by increasing litter and pig birth and weaning weights, reducing the number of stillborn pigs and increasing the number of pigs born alive in the subsequent reproductive cycle. Sow diets of this invention include carnitine, such as L-carnitine or L-carnitine salts. Carnitine is generally added to the swine feed formulation in the amount of from about 5 to about 5,000 ppm.

Carnitine supplemented diets for gestating and lactating swine

The present invention relates to a method of feeding carnitine supplemented diets to sows during the period of gestation or during both gestation and lactation periods. The method enhances pork productivity by increasing litter and pig birth and weaning weights, reducing the number of stillborn pigs and increasing the number of pigs born alive in the subsequent reproductive cycle. Sow diets of this invention include carnitine, such as L-carnitine or L-carnitine salts. Carnitine is generally added to the swine feed formulation in the amount of from about 50 to about 5,000 ppm.

An effective amount of carnitine is administered to broiler breeder type poultry to prevent sudden death syndrome. In the preferred embodiment, a carnitine supplemented diet is fed to broiler breeder type chickens in a feed composition during a period of time preceding peak egg production. The feed composition preferably contains between 5 and 1000 ppm of carnitine.

Carnitine supplemented diet to prevent sudden death syndrome in breeder

Modified tall oil supplemented pig diet is provided which increases the average daily gain and improves the carcass characteristics of pigs. The diets of the invention include from about 12-50% by weight of total protein (e.g., from corn and soy) and from about 0.25% to about 0.75% by weight modified tall oil. In one embodiment, the diet includes a mixture of conjugated linoleic acids having a specific fatty acid profile.

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Manhattan, KS, United States of America

Kevin Q Owen