Lynx Therapeutics, Inc.

Illumina Corporation

Ricoh Corporation

Solexa, Inc.

Ricoh Corporation and Ricoh Company, Ltd.

Kevin P Corcoran

Sydney Brenner

Michael C Pallas

George Stefan Golda

John Bridgham

James D Allen

Steven M Blonstein

Koichi Ejiri

Sanjiv Arora

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

System and apparatus for sequential processing of analytes

Method for sequential sequencing nucleic acids

Planar arrays of microparticle-bound polynucleotides

An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

A color image compression system and method provides an improved technique of combining various image processing techniques to obtain high quality color image compression. The present invention provides color image compression, especially high quality original images that require up to 24 bits of data per pixel. The present invention utilizes a delta quantizing technique between an array of pixels to provide an improved color image compression aspect.

High quality color image compression system

A high quality image scanner is provided which processes multiple scanned images into a composite image with a large dynamic range. The two scanned images are processed to identify maximum local similarity.

High quality image scanner

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Fremont, CA, United States of America

Kevin P Corcoran