The University of British Columbia

Kevin Ou

Andre Wild

Timothy Leaver

Robert James Taylor

Euan Ramsay

Colin Walsh

Aysha Ansari

John K Jackson

Anitha Thomas

Mu Chiao

R James Taylor

Fatemeh N Pirmoradi

Gesine Heuck

Euan Ramsey

The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Continuous flow microfluidic system

The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.

Disposable microfluidic cartridge

Methods and devices for making particles at small volumes.

Device for formulating particles at small volumes

Drug delivery devices responsive to at least one external stimulus are described, along with methods for their preparation and use. The devices can be configured to respond to the stimulus, providing 'on demand' release of one or more deliverables such as pharmaceutical drugs.

Remotely controlled drug delivery systems

Growing community of inventors

Toronto, Canada

Kevin Ou