Intrapace, Inc.

Aerocrine Ab

Apieron Biosystems Corp.

Circassia Ab

Aperon Biosystems Corp.

Mission Medical Devices, Inc.

Apieron Inc.

Kevin Nason

Bhairavi Parikh

Jonathan P Fay

Bryan Patrick Flaherty

James Stone

Mir A Imran

Ted W Layman

Olivier K Colliou

David J Chazan

Harm TenHoff

John Kaiser

Bobby E Rogers

Gino Kang

David James Anvar

John Hammerman

Johnathan Fay

Bhairavi R Parikh

Bryan P Flaherty

Jonathan Fay

The flow rate of a gaseous sample of exhaled breath through an analytical device is controlled by a pump, and in certain embodiments two pumps. Placement of the analyte sensor in a secondary stream branching off of the primary stream through the device offers further control over the manner, duration, and quantity of the breath that is placed in contact with the sensor.

Controlling flow of exhaled breath during analysis

A device, system and method for diagnosing and treating gastric disorders is provided. A submucosal gastric implant device is placed within the submucosal layer of a patient's stomach wall. The device in one embodiment provides electrical stimulation of the stomach wall and may use multiple electrode pairs for sequential stimulation. The device may also have other functional aspects such as a sensor for sensing various parameters of the stomach or stomach environment, or a therapeutic delivery device. The implant may be programmed to respond to sensed information or signals. The device may be modular with a portion of the device accessible outside the stomach wall for removal and replacement. An endoscopic delivery system prepares and delivers the functional device through the esophagus and into the stomach where it is placed through an opening in the mucosa into the submucosal layer of the stomach wall. The endoscopic instruments may be used to prepare a cavity in the submucosal layer of the stomach wall and deliver the device to the prepared cavity and if appropriate close the opening in the mucosa.

Submucosal gastric implant device and method

The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.

Disposable sensor for use in measuring an analyte in gaseous sample

Disposable sensor for use in measuring an analyte in a gaseous sample

A device, system and method for diagnosing and treating a patient is provided where a functional device is attached to a stomach wall. The device in one embodiment provides electrical stimulation of the stomach wall. The device may also have other functional aspects such as a sensor for sensing various parameters of the stomach or stomach environment, or a substance delivery device. The implant may be programmed to respond to sensed information or signals. The device may be modular with a portion of the device accessible for removal and replacement. In one embodiment, an endoscopic delivery system delivers the functional device through the esophagus and into the stomach where it is attached the stomach wall with the assistance of a suction used to stabilize the tissue of the stomach wall. The device includes a chamber for receiving tissue of the stomach wall for attachment where a vacuum pressure is applied through the chamber to draw the tissue into the chamber.

Endoscopic instrument for engaging a device

The present invention is a system and method of conditioning the sample and surrounding environment of an exhaled breath sensor. It includes (i) using a particular molecular sieve for a triple purpose: (a) maintaining the sensor at a constant relative humidity during storage, (b) equilibrating the incoming breath stream to the same relative humidity as the sensor, and (c) eliminating the analyte from the environment around the sensor during storage. The present invention also includes removal of interfering components from the exhaled breath, such as carbon dioxide, as well as a thermal management technique.

Sample conditioning and environmental control techniques for gas sensor

Gastric device and suction assisted method for implanting a device on a stomach wall

An injection valve includes a housing having an inlet, an outlet, and a fluid channel extending between the inlet and the outlet. A piston is slidable within a bore of the housing between a first position wherein the piston is relatively far from the closed end and a second position wherein the piston is relatively near to the closed end. A biasing spring biases the piston toward the first position. The piston closes and seals the inlet when the piston is in the first position and allows fluid to pass from the inlet to the fluid channel to the outlet when the piston is in the second position. A piston seal is formed between the piston and a wall of the bore, dividing the bore into a unsealed chamber and a sealed chamber adjacent to the closed end. There is no vent between the sealed chamber and an exterior of the housing. Pressure differences between the unsealed chamber and the sealed chamber that adversely affect performance may be minimized by providing a deformable membrane or a gas accumulator communicating with the sealed chamber, or providing an initial pressure differential wherein a gas pressure within the sealed chamber is less than a gas pressure within the unsealed chamber, when the piston is in its first position.

Nonvented needle-free injection valve

Growing community of inventors

Menlo Park, CA, United States of America

Kevin Nason