University of Nottingham

Massachusetts Institute of Technology

Locate Therapeutics Limited

University of Pittsburgh

Locate Theapeutics Limited

Locate Bio Limited

Kevin Morris Shakesheff

Robin Andrew Quirk

Robert Samuel Langer

James Dixon

Chris Denning

Scott M Cannizzaro

Patrick Ginty

Stephen Francis Badylak

Aliasger Karimjee Salem

Brian Saunders

Martyn Christopher Davies

Lisa Jane White

Bernhard G Mueller

Michael J Sawkins

Antonio Leonardi

Cameron Alexander

Helen Celia Cox

Liang He

Wenxin Wang

Nikin Patel

Ali Karimjee Salem

Martyn Davies

The invention relates to a scaffold material composition for forming a solid tissue scaffold, the composition comprising a plurality of hollow polymer pellets, each pellet comprising an open hollow extending through the pellet, and wherein the plurality of hollow polymer pellets are capable of interlinking and setting into a solid scaffold. The invention further relates to associated compositions, uses, method of treatment and kits associated with such material.

Tissue scaffold and scaffold composition

This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.

Transduction

A composition comprising polymer particles and a carrier, wherein the polymer particles are a mixture of at least a first polymer and a second polymer, wherein the first polymer is at least partially soluble or dispersible in the carrier, and wherein the polymer particles are arranged such that they can join together to form a scaffold of polymer particles, and wherein the composition is administrable to a human or non-human animal.

Injectable scaffold composition and related methods

Injectable scaffold composition

Methods of manufacturing a bone-derived extracellular matrix (bECM) product are provided. Also provided are bECM products and methods of using those products.

Bone-derived extra cellular matrix gel

The invention provides polymer particles that are obtainable by a method selected from emulsion methods, diffusion methods and evaporation methods carried out in the presence of surface-engineering surfactant which is one or more polymer that displays a lower critical solution temperature, in aqueous media, that is between 10 to 90&#xb0; C., this polymer being the polymerization product of one or more monomer selected from polymerisable alkyleneglycol acrylate monomers and polymerisable alkyleneglycol methacrylate monomers. The polymer particles can be used in controlled release applications, such as flavour release applications, fragrance release applications and biomedical applications. The invention also provides a cell support matrix comprising the polymer particles.

Polymer particles prepared from polymerisable alkylene glycol (meth) acrylate monomers

An open porous matrix of particulate material for in vivo use in or on a target tissue in medicine, the matrix comprising particles cross-linked with one another so as to define pores there between and uses therefor are described.

Porous matrix comprising cross-linked particles

The invention provides a biodegradable and biocompatible polymer article having a surface wherein a biologically active ligand is provided on said surface in a spatially controlled pattern. The pattern may be formed using a poly(dimethyl siloxane) mold. The biologically active ligand may be attached to the polymer article by a biotin-avidin-biotin linkage.

Surface coating spatially controlled patterns

The present invention provides a novel surface engineering strategy that uses biomolecular interactions to immobilize surface modifying ligands on biomaterial architectures. The surface modified compositions resulting from the inventive method are useful in many contexts, including, but not limited to, scaffolds for tissue engineering and as vehicles for site specific drug delivery. In one preferred embodiment, the biomolecular interaction is achieved by using an &ldquo;anchor-adapter-tag&rdquo; system, in which an adapter which can interact specifically and with high selectivity with an anchor molecule (present on the biodegradable surface) and a tag (bound to the ligand to be immobilized) simultaneously is used in attaching the ligand to the surface in a manner which is stable in vitro or in vivo. In another preferred embodiment, the biomolecular interaction is achieved by using an &ldquo;anchor-tag&rdquo; system, in which the anchor simultaneously acts to effect attachment to the architecture and mediate direct interaction with the tag.

Modification of surfaces using biological recognition events

Growing community of inventors

Nottingham, United Kingdom

Kevin Morris Shakesheff