Astrazeneca Ab

Astrzenca Ab

Kevin Michael Foote

Andrew Peter Thomas

Johannes Wilhelmus Maria Nissink

Paul Turner

David Buttar

Maria-Elena Theoclitou

Keith Hopkinson Gibson

Zbigniew Stanley Matusiak

Michael Howard Block

Benedicte Delouvrie

Alexander Graham Dossetter

Jean Claude Arnould

Maryannick Andree Lamorlette

Annie Hamon

Laurent Francois Andre Hennequin

Francis Thomas Boyle

Patrick Ple

David R Brittain

Bernard Christophe Barlaam

Clifford David Jones

Craig Samuel Donald

Wayne Brailsford

Johannes Wilhelmus Nissink

There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.

Compounds

Methods of treating cancer with a pyrazole derivative

There is provided pyrimidinyl compounds of Formula (I), wherein: or pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Chemical compounds

N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl]-4-(3,4-dimethylpiperazin-1-yl)benzamide and salts thereof

The present invention relates to compounds that inhibit of focal adhesion kinase function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases such as cancer. 

Pyridine compounds

N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-(3,4-dimethylpiperazin-1-yl)benzamide and salts thereof

N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof

The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R, R, R, Rand Rare as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.

The invention concerns quinazoline derivatives of Formula (I) wherein each of Z, m, R, n, R, Zand Rhave any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.

Quinzoline derivatives for use in the treatment of cancer

The use of a compound of formula (I) in the manufacture of a medicament for the treatment, in a warm-blooded animal, of disorders mediated by the neuropeptide Y5 receptor: wherein: Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described.

Carbazole derivatives and their use as NPY5 receptor antagonists

The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt thereof, a process for t he preparation of a compound of Formula (1) and pharmaceutical compositions of a compound of Formula (1).

Substituted quinolines as antitumor agents

Growing community of inventors

Macclesfield, United Kingdom

Kevin Michael Foote