Warner-lambert Company

Alnylam Pharmaceuticals, Inc.

Kevin Matthew Schlosser

Haile Tecle

Helen Tsenwhei Lee

Karen Elaine Sexton

Roy Thomas Winters

Jessica Elizabeth Reed

Stephen Alan Fakhoury

Steven L Colletti

Weimin Wang

Robert M Garbaccio

Rubina G Parmar

David M Tellers

Quang T Truong

Jing Liao

Marina Busuek

J Michael Williams

Robert A Kowtoniuk

Tao Pei

Erin Guidry

Craig A Parish

Stephanie E Barrett

Sandra C Tobias

Jacob H Waldman

The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.

Poly(amide) polymers for the delivery of oligonucleotides

This invention provides quinazoline compounds of the formula: 

4-phenylamino-quinazolin-6-yl-amides

This invention provides quinazoline compounds of the formula: wherein: Ris halo; Ris H or halo; Ris a) C-Calkyl, optionally substituted by halo; or b) &#x2014;(CH)-morpholino, &#x2014;(CH)-piperidine, &#x2014;(CH)-piperazine, &#x2014;(CH)-piperazine-N(C-Calkyl), &#x2014;(CH)-pyrrolidine, or &#x2014;(CH)-imidazole; n is 1 to 4; Ris &#x2014;(CH)-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C-Calkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH, NH(C-Calkyl) or N(C-Calkyl); m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

This invention provides quinazoline compounds of the formula: wherein: Ris halo; Ris H or halo; Ris a) C-Calkyl, optionally substituted by halo; or b) &#x2014;(CH)-morpholino, &#x2014;(CH)-piperidine, &#x2014;(CH)-piperazine, &#x2014;(CH)&#x2014;-piperazine-N(C-Calkyl), &#x2014;(CH)-pyrrolidine, or &#x2014;(CH)-imidazole; n is 1 to 4; Ris &#x2014;(CH)-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C-Calkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH, NH(C-Calkyl) or N (C-Calkyl); m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

Growing community of inventors

Ann Arbor, MI, United States of America

Kevin Matthew Schlosser