Harvard College

California Institute of Technology

Vanderbilt University

Premier Specialty Brands LLC

President and Fellows of Havard College

Desora Inc.

Kevin Kit Parker

Josue A Goss

Adam Walter Feinberg

Donald Elliot Ingber

Geraldine A Hamilton

Anna Grosberg

Anthony Bahinski

Patrick W Alford

Daniel Levner

Christopher David Hinojosa

Robert Cunningham

Holly M Golecki

Johan Ulrik Lind

Mark Daniel Brigham

Grant Michael Gonzalez

George M Whitesides

Sergey S Shevkoplyas

Benjamin D Pope

Elizabeth Olayinka Ogunbiyi

Ashutosh Agarwal

Megan Laura McCain

Mohammad Reza Badrossamay

Kwanwoo Shin

Aaron L Glieberman

Alexander Feigel

Po-Ling Kuo

Megan O'Grady

Sung-Jin Park

Jennifer Ann Lewis

John P Wikswo

Ronald S Reiserer

Travis Alexander Busbee

Dmitry A Markov

David Edward Cliffel

Philip C Samson

Lisa J McCawley

Frank Emmanuel Block

John Oluseun Dabiri

Joost Johan Vlassak

Robert A Brennan

John A Mclean

Anna Herland

Jennifer Robin McKenzie

Michel Nicholas Maalouly

Qihan Liu

Olivier F Henry

John P Ferrier

Alanna R Gannon

Joseph A Festa

Michel Maalouly

Hongyan Yuan

Ben M Maoz

Ian Perkins

Christophe Chantre

Andrew K Capulli

Janna C Nawroth

Chin-Lin Guo

Patrick Healy Campbell

Nina R Sinatra

John F Zimmerman

Kevin L Shores

Alexander Peyton Nesmith

Huibin Chang

Luca Cera

Josue Adrian Goss

Golecki Holly M M

Some embodiments provide a microfluidic cartridge for automatically hydrodynamically loading objects (e.g., cell clusters) into traps in parallel trapping channels with one object per trap, methods of making such cartridges and methods of use of such cartridges.

Microfluidic trapping chip and uses thereof for culture and assay of cell clusters and objects

The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Integrated human organ-on-chip microphysiological systems

The present invention provides methods for preparing an alpha-keratin solution comprising alpha-keratin protofibrils and intermediate filaments in liquid crystal phase and uses thereof for fabricating, e.g., shape-memory polymeric fibers, yarns, threads, fabrics, structures and objects.

Alpha-keratin solutions comprising alpha-keratin intermediate filaments in liquid crystal phase, methods of preparation, and uses thereof

Systems and methods for focused direction deposition of a micron or nanometer dimension polymeric fiber and materials of such fibers are described herein. Systems and methods employ one or more gas flows to entrain and deflect fibers produced by a rotary jet spinning system forming a focused fiber stream. Some embodiments enable control of alignment and distribution of the fibers with a relatively high fiber throughput.

Focused rotary jet spinning devices and methods of use thereof

Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.

Immersed rotary jet spinning (iRJS) devices and uses thereof

An insert is provided for use in a cooking apparatus that alters the pressure profile, air velocity profile, and airflow pattern within said cooking apparatus in order to achieve a cyclonic air profile around food to be cooked. The insert includes a ring-shaped insert body formed by a continuous sidewall. The sidewall has an external surface and an internal surface, and a top end and a bottom end. The insert also includes a deflection plate.

Insert for cooking apparatus

The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.

Methods for producing mature adipocytes and methods of use thereof

Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies.

Photosensitive cardiac rhythm modulation systems

An organ-on-chip device for monitoring a biological function and including a membrane layer located at an interface region between a top microchannel and the a microchannel. The membrane includes a first type of cells forming a barrier between the top microchannel and the bottom microchannel. The device further includes a top layer having a first plurality of transendothelial electrical resistance (TEER) measurement electrodes for enabling direct monitoring of cell function and electrical activity of the first type of cells on the membrane. The device also has a multi-electrode array (MEA) layer with a second plurality of TEER measurement electrodes for enabling direct monitoring of cell function and electrical activity of a second type of cells on the MEA layer.

Integrated multi-electrode array and trans-endothelial electrical resistance in organ-on-a-chip microsystems

Microfluidic systems including a housing configured to receive a cartridge, the cartridge including a plurality of wells for receiving one or more biological cells are described herein. The microfluidic systems include a structure with channels for introducing a medium into the housing and through channels the cartridge. Microfluidic systems including a housing configured to receive a cartridge, the housing including channels for loading one or more biological cells within wells of the cartridge are described herein. Three-dimensional scaffolds, devices, and systems comprising such scaffolds that mimic the in vivo structure, physical properties, and protein composition of extracellular matrix surrounding pancreatic islet cells and adipocytes, and the use of such compositions, devices and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications are also described herein.

Cartridge-based system for long term culture of cell clusters

Devices, systems, and computer-readable medium are provided for a barbecue smoker device. A barbecue smoker device is provided, that includes a multi-wall container, a food platform, a heat source, an air vent at the top of the barbecue smoker device, an air flow control mechanism at the lower portion of the barbecue smoker device, and a plurality of sensors coupled to the barbecue smoker device. The barbeque smoker device may include a control device for automated control of the air flow control mechanism. A system for remotely controlling a barbecue smoker device is provided, where the system includes a barbecue smoker device including a processor and a display unit, a mobile device in wireless communication with the barbecue smoker device, and the mobile device displaying a graphical user interface that is configured to receive input from a user causing a configuration change in the barbecue smoker device.

Systems and methods for an automated barbecue smoker

Exemplary embodiments provide systems, devices and methods for simultaneously measuring mechanical and electrophysiological tissue responses (e.g., contractile function, or the like).

Contractile function measuring devices, systems, and methods of use thereof

Growing community of inventors

Cambridge, MA, United States of America

Kevin Kit Parker