Enclear Therapies, Inc.

Kevin Kalish

Anthony DePasqua

Gianna N Riccardi

Marcie Ann Glicksman

William X Siopes

Kevin Eggan, Jr

Alan D Watson

Kasper Roet

Ching-Hua Tseng

Rajan Patel

Joshua G Vose

Manuel A Navia

Manual A Navia

Cerebrospinal fluid (CSF) and other fluid amelioration systems completely or partially implantable within a mammalian subject and associated methods include a substrate and an agent for amelioration of a toxic biomolecule present in the CSF or fluid, wherein the agent is disposed on or within the substrate.

Methods of amelioration of cerebrospinal fluid and devices and systems therefor

A CSF management method for use with a patient forms a closed loop CSF circuit between two points on the patient's body. The CSF circuit has a therapeutic inlet to receive a therapeutic material (e.g. a drug), and a pump having a pump outlet to direct CSF along the CSF circuit. The method controls the pump to direct CSF from the pump outlet at a CSF rate that is different from the natural flow rate (i.e., the natural CSF flow rate). The therapeutic material is added to the CSF via the therapeutic input at a therapeutic rate. The CSF rate is different than the therapeutic rate and/or may be greater than the therapeutic rate. Alternative methods may control a bolus drug infusion to localize the application to a target region.

Subarachnoid fluid management method and system with varying rates

Subarachnoid fluid management method and system

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Newburyport, MA, United States of America

Kevin Kalish