The Procter Gamble Company

Kevin John Mills

Stevan David Jones

Robert Scott Youngquist

John Erich Oblong

Deborah Ruth Finlay

Charles Carson Bascom

Karl Shiqing Wei

Tomohiro Hakozaki

Jun Xu

John Crist Bierman

Qing Stella

Yiping Sun

Robert Lloyd Binder

Jason Edward Cook

Ping Hu

Kenneth Robert Wehmeyer

Makio Tamura

Jesus Velazquez

Kathleen Marie Kerr

Feng Wang

Raymond Alan Grant

Angela Marie Fieno

Supriya Punyani Bareja

Tanuja Chaudhary

Michael Keith Robinson

Leo Timothy Ii Laughlin

Raymond Alan Gant

Raymond Grant

Angela Fieno

Methods of identifying potential skin moisturizing actives for the treatment of dry skin and method of formulating a moisturizing skin care composition using actives identified by the method. Moisturizing agents can be identified by comparing the transcriptional profile of a skin tissue sample contacted by a test agent to a negative or positive control to determine if the regulation of certain genes corresponds to the appropriate direction of regulation indicated by the control. Agents identified as skin moisturizing agents can then be incorporated into a skin moisturizing composition.

Method of identifying cosmetic agents for moisturizing skin

Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for treatment of dandruff, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both are provided. Methods for developing in vitro models of skin disease and models for specific skin diseases are also provided.

Systems, models and methods for identifying and evaluating skin-active agents effective for treating dandruff/seborrheic dermatitis

Methods and systems for constructing a gene expression signature representative of a number of biological conditions, systems and methods for determining functional relationships between a skin-active agent and skin conditions of interest, and methods and systems for identifying skin-active agents with broad spectrum activity are provided.

Systems, models and methods for identifying and evaluating skin-active agents effective for treating an array of skin disorders

A method of treating a skin condition including applying a rinse-off multi-phase cleansing composition including a cleansing phase including an anionic surfactant and zinc pyrithione and a benefit phase including a benefit agent.

Methods of cosmetically treating skin conditions with a cosmetic personal cleansing composition

Provided are methods and systems for determining functional relationships between ex vivo skin models and an inflammatory skin condition. Also provided are methods and systems for identifying modulators of inflammation of skin, as well as the use of modulators identified by such methods or systems for the preparation of cosmetic compositions, personal care products, or both.

Human ex vivo skin model and its use in methods of identifying modulators of skin inflammation

Cosmetic compositions for alleviating the signs of photoaged skin containing a substituted azole. Methods for alleviating the signs of photoaged skin that include applying a cosmetic composition comprising substituted azole to a target UV-exposed skin surface. The substituted azole compound present in the cosmetic composition may be 1-phenylimidazole, 4-phenylimidazole or a combination thereof. An effective amount of the cosmetic composition is applied to the target skin surface for a period of time sufficient to alleviate at least one sign of photoaging.

Cosmetic compositions containing substituted azole and methods for alleviating the signs of photoaged skin

Methods of improving the appearance of aging skin that include applying a cosmetic composition to a target skin surface having one or more signs of aging. The cosmetic composition includes a substituted azole. In some instances, the substituted azole compound is 1-phenylimidazole, 4-phenylimidazole, or combinations thereof. An effective amount of the cosmetic composition is applied for a period of time sufficient to improve the appearance of at least one sign of aging skin.

Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin

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Goshen, OH, United States of America

Kevin John Mills