Massachusetts Institute of Technology

Kevin John Kauffman

Daniel Griffith Anderson

Joseph R Dorkin

Owen Shea Fenton

James C Kaczmarek

Rebecca L McClellan

Asha Kumari Patel

Luke Hyunsik Rhym

Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.

Poly(beta-amino esters) and uses thereof

Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of Ris independently optionally substituted C-Calkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof. 

Alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof

The present disclosure relates to improvements in the selection and formulation of PBAE polymers using a design of experiment approach, in which statistical methods are used to limit possible experimental conditions. The present disclosure relates to improved PBAE polymers and formulations.

Polymer-lipids and compositions

Poly (beta-amino esters) and uses thereof

Growing community of inventors

Somerville, MA, United States of America

Kevin John Kauffman