University of Illinois

Northwestern University

Kevin Jerome Schwarz

Jeffrey S Moore

Nancy R Sottos

Michael Christopher Jewett

Justine E Paul

Katherine J Stawiasz

Joongoo Lee

Kenneth E Schwieter

Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

Expanding the chemical substrates for genetic code reprogramming

A method of light-promoted frontal ring-opening metathesis polymerization includes providing a monomer solution including dicyclopentadiene, a ruthenium-based catalyst and a phosphite inhibitor, and exposing the monomer solution to ultraviolet light having a wavelength in a range from 315 nm to 400 nm, thereby initiating an exothermic polymerization reaction and generating a self-propagating polymerization front. The polymerization front moves through the monomer solution and polymerizes the dicyclopentadiene.

Method of light-promoted frontal ring-opening metathesis polymerization

Growing community of inventors

Champaign, IL, United States of America

Kevin Jerome Schwarz