Flagship Pioneering Innovations V, Inc.

Massachusetts Institute of Technology

Kevin James Lebo

Avak Kahvejian

Erica Gabrielle Weinstein

Dhananjay Maniklal Nawandar

Ryan D Tedstone

Simon Delagrave

Jared David Pitts

Nathan Lawrence Yozwiak

Fernando Martin Diaz

Ron Weiss

Jin Huh

This invention relates generally to viral vectors and viral particles based on Anelloviruses, which can be used to deliver an agent (e.g., an exogenous effector or an endogenous effector, e.g., a therapeutic effector) to a cell (e.g., a cell in a subject to be treated therapeutically). Described herein are anellosomes, anellovectors, and compositions and uses thereof.

Anellovirus compositions and methods of use

Provided herein are genetic circuits and cell state classifiers for detecting the microRNA profile of a cell. In some embodiments, the cell state classifiers described herein utilize an endoribonuclease and a self-amplifying RNA molecule for controlling the expression of an output molecule. In some embodiments, the cell state classifiers described herein are encoded on a single RNA transcript, which is then processed to produce individual genetic circuits that function independently. The genetic circuits and cell state classifiers described herein may be used in various applications (e.g., therapeutic or diagnostic applications).

RNA-based regulatory technologies for miRNA sensors

This invention relates generally to viral vectors and viral particles based on, which can be used to deliver an agent (e.g., an exogenous effector or an endogenous effector, e.g., a therapeutic effector) to a cell (e.g., a cell in a subject to be treated therapeutically). Described herein are anellosomes, anellovectors, and compositions and uses thereof.

Growing community of inventors

Weymouth, MA, United States of America

Kevin James Lebo