Esm Technologies, LLC

Esm Holdings, LLC

Ruff, Kevin J.

Kevin J Ruff

The present invention relates to the use of eggshell membrane compositions to activate levels of nuclear factor kappa-light-chain-enhancer of activated B cells ('NF-&#x3ba;B') in the gut of a host in need thereof and methods of treating conditions related to NF-&#x3ba;B dysregulation.

Methods for treating nuclear factor kappa-light-chain-enhancer of activated B cell (NF-KB) dysregulation in a host in need thereof using eggshell membrane compositions

The present invention relates to the use of eggshell membrane compositions to activate levels of nuclear factor kappa-light-chain-enhancer of activated B cells ('NF-&#x3ba;B') in the gut of a host in need thereof and methods of treating conditions related to NF-KB dysregulation. The herein invention provides a method for activating NF-&#x3ba;B in the gut of a host in need thereof. The method comprises orally administering an effective amount of a composition consisting essentially of eggshell membrane, and/or eggshell membrane isolates and/or eggshell membrane hydrolysates for activation of NF-&#x3ba;B to the host.

Methods for treating nuclear factor kappa-light-chain-enhancer of activated B cell (NF-&#x3ba;B) dysregulation in a host in need thereof using eggshell membrane compositions

The invention provides a method for determining the efficacy of compositions used to treat articular joint conditions in mammals. The method includes measuring the change in levels of one or more cartilage degradation biomarkers in a mammal from before exercise and after exercise, then administering a composition used to treat articular joint conditions to the mammal, and measuring the change in levels of one or more cartilage degradation biomarkers in the mammal from before exercise and after exercise.

Method for evaluating articular joint therapeutics

In one aspect, the invention relates to methods for treating a disease or condition associated with abnormal glucose metabolism. In another aspect, the invention relates to a method for reducing incidence or progression of insulin-dependent diabetes mellitus. The methods include orally administering to a mammal in need thereof an effective amount of a composition, which includes a naturally occurring material derived from eggshell, eggshell membrane, or a combination thereof.

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Carthage, MO, United States of America

Kevin J Ruff