Aventis Pharmaceuticals Inc.

Abbott Laboratories Corporation

University of Pennsylvania

Kevin J Lynch

Michael C Jaye

Dilip V Amin

Victoria J South

John A Krawiec

Kim-Anh Thi Doan

Edward C Burgard

Tim Van Biesen

Daniel J Rader

Edward B Touma

Cyrille Maugeais

Wende Niforatos

Randy E Metzger

Dawn Marchadier

Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.

Antibodies against LLG polypeptides of the triacylglycerol lipase family

The present invention relates to LLG polypeptides, which are polypeptides of the triacylglycerol lipase family, and fragments thereof, antibodies against such polypeptides, nucleic acids encoding such polypeptides, and antisense nucleic acids derived from such nucleic acids. The invention relates also to therapeutic compositions and methods comprising the above. In addition, the invention relates to the preparation of LLG polypeptides using recombinant technology and to the use of LLG polypeptides to screen for agonists and antagonists thereof.

LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies

The present invention relates to compositions for use in raising or lowering the level of LIPG polypeptide in a patient. Embodiments of the composition include compositions comprising: an anti-sense nucleic acid; a neutralizing antibody; an intracellular binding protein; an inhibitor which inhibits the enzymatic activity of LIPG polypeptide; an inhibitor which inhibits the expression of LIPG gene; a ribozyme; an LIPG polypeptide; an enhancer which increases the enzymatic activity of LIPG polypeptide; or an enhancer which increases the expression of LIPG gene. The invention relates also to methods for using the above compositions. In addition, the invention relates to a method for diagnosing a predisposition to lower cholesterol, a method for determining whether a test compound can inhibit the enzymatic reaction between LIPG polypeptide and HDL cholesterol, and methods for determining whether a test compound can enhance the enzymatic reaction between LIPG polypeptide and LDL or VLDL cholesterol.

Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol

Human P2X,and P2X,purinergic receptor polypeptides are provided. Nucleic acid molecules encoding the aforementioned human P2X receptor polypeptide, and vectors and host cells containing such nucleic acid molecules, are also provided. In addition, methods are provided for producing these P2X receptor polypeptide, as are methods of using such polypeptides and host cells that express the same to screen for compounds having activity on P2X,and P2X,receptors. Further, therapeutic uses involving aspects of these receptors are contemplated.

Nucleic acids encoding a functional human purinoreceptor P2X2 and P2X4, and methods of production and use thereof

Human P,X,and P,X,purinergic receptor polypeptides are provided. Nucleic acid molecules encoding the aforementioned human P,X receptor polypeptide, and vectors and host cells containing such nucleic acid molecules, are also provided. In addition, methods are provided for producing these P,X receptor polypeptide, as are methods of using such polypeptides and host cells that express the same to screen for compounds having activity on P,X,and P,X,receptors. Further, therapeutic uses involving aspects of these receptors are contemplated.

Nucleic acids encoding a functional human purinoreceptor P2X3 and P2X6, and methods of production and use thereof

Growing community of inventors

Gurnee, IL, United States of America

Kevin J Lynch