Agilent Technologies, Inc.

University of Texas System

Kevin J Luebke

Michael P Caren

Nicholas Michael Sampas

Paul K Wolber

Steven M Lefkowitz

Glenda Choate Delenstarr

Leslie B Overman

Jeffery R Sampson

Kathlynn C Brown

Methods for substantially improved detection and analysis in nucleic acid hybridization assays are described. The methods provide the reliable estimation of background signal which derives primarily from nonspecific hybridization. The invention is useful in chemical, biological, medical and diagnostic techniques, as well as for drug discovery.

Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same

Methods are provided for depositing a quantity of fluid onto the surface of an array. In the subject methods, a thermal inkjet head loaded with the fluid is positioned in opposing relationship to, e.g. over, the array surface. Actuation of the thermal inkjet results in the expulsion of a quantity of fluid onto the array surface. The subject methods find particular use in array-based binding assays in which an array of binding agents is employed for the detection of an analyte(s), particularly array-based hybridization assays.

Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids

Various embodiments of the present invention provide both apparatus and method for the patterning of cells onto non-adhesive substrates and the controlled regulation of cells through the use of photoactivated cellular morphogenic factors.

Complex multicellular assemblies ex vivo

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Dallas, TX, United States of America

Kevin J Luebke