Willow Laboratories, Inc.

Cercacor Laboratories, Inc.

Kevin Hughes Pauley

Hung The Vo

Cristiano Dalvi

Jesse Chen

Jeroen Poeze

Ferdyan Lesmana

Sean Merritt

Ruiqi Long

Massi Joe E Kiani

Venkatramanan Krishnamani

Stephen L Monfre

Gregory A Olsen

Mathew Paul

Sai Kong Frank Lee

Mohamed Kheir Diab

Thomas B Blank

Frank Lee

Anando Devadoss

Gerry Hammarth

Sergei Petrovich Balashov

Derek Treese

Merlin Stonecypher

Anderson Briglia

Sahand Pirbadian

Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.

Medical monitoring device for harmonizing physiological measurements

Embodiments of the present disclosure provide insulin formulations having a near neutral pH and improved pharmacokinetic/pharmacodynamic properties, and uses in insulin infusion devices that may provide extended infusion period up to 7-14 days. Also provided are systems for administering insulin, the system may include a first reservoir, a second reservoir, an insulin pump configured to administer contents of the first reservoir or the second reservoir, and one or more hardware processors in communication with the insulin pump.

Insulin formulations and uses in infusion devices

An optical physiological sensor configured to perform high speed spectral sweep analysis of sample tissue being measured to non-invasively predict an analyte level of a patient. An emitter of the optical physiological sensor can be regulated to operate at different temperatures to emit radiation at different wavelengths. Variation in emitter drive current, duty cycle, and forward voltage can also be used to cause the emitter to emit a range of wavelengths. Informative spectral data can be obtained during the sweeping of specific wavelength regions of sample tissue.

Non-invasive optical physiological differential pathlength sensor

A system which provides closed loop insulin administration is disclosed. The system includes redundant glucose sensors which may be interleaved in order to provide monitoring when one of the glucose sensors is in a settling period. The system may include a disease management unit which includes both a glucose sensor and an insulin pump. A closed loop disease management system which bases insulin administration on accurate glucose measurements may improve a patient's quality of life.

Method of operating redundant staggered disease management systems

Systems and methods for a comprehensive and personalized approach to health and lifestyle coaching are described. The system may determine health metrics of a user based on detected physiological parameters. The health metrics may be used to determine health recommendations and transmit feedback to the user based on user compliance with the recommendations.

Personalized health coaching system

A minimal action, invasive blood constituent device can streamline the process for the self-monitoring of blood-related tests by holding and facilitating the use of some or all of the tools for obtaining and testing a blood sample. The device can include a slider, that when pumped, causes the device to spring-load a lancet and eject a testing strip. The device can include a trigger that, when pressed, activates the lancet by unloading the spring. A strip-lancet apparatus can combine the roles of two disposable products—a testing strip and a lancing needle—into an apparatus that can be configured for piercing the testing site as well as receiving the blood sample. A testing strip apparatus can facilitate the use and/or disposal of testing strips. A lancet apparatus can facilitate the use and/or disposal of lancets.

Self-contained minimal action invasive blood constituent system

A noninvasive physiological sensor can include a first body portion and a second body portion coupled to each other and configured to at least partially enclose a user's finger. The sensor can further include a first probe coupled to one or more emitters and a second probe coupled to a detector. The first probe can direct light emitted from the one or more emitters toward tissue of the user's finger and the second probe can direct light attenuated through the tissue to the detector. The first and second probes can be coupled to the first and second body portions such that when the first and second body portions are rotated with respect to one another, ends of the first and second probes can be moved in a direction towards one another to compress the tissue of the user's finger.

Noninvasive physiological sensor

Systems, methods, and apparatuses for enabling non-invasive, physiological sensors to obtain physiological measurements from a region of tissue of a patient are disclosed. Anchoring components can attach to patient tissue sites and sensor heads such that the tissue sites do not move during sensing. Interlocking mechanisms maintain tissue sites within a limited range of horizontal movement and vertical distance from the sensor head.

Systems and methods for securing a tissue site to a sensor

Various spirometer-inhaler systems and devices are disclosed. The spirometer-inhaler system may estimate physiological parameters of a user based on the user's inhaled and/or exhaled breaths received by the spirometer-inhaler device. The spirometer-inhaler device may comprise one or more flow paths. A first flow path may direct medication from a medicine canister to an opening of the device. A second flow path may direct a user's exhaled breath from the opening of the device to one or more flow measurement devices.

Combination spirometer-inhaler

Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from the same tissue site. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus. The multi-sensor apparatus can orient the plurality of non-invasive, physiological sensors such that each of the plurality of non-invasive, physiological sensors obtains physiological data from the same or a similar location.

Assembly for medical monitoring device with multiple physiological sensors

Some embodiments disclosed herein pertain to indicator compounds used to detect the presence of and/or an amount of an analyte. In some embodiments, the indicator compounds are fusion proteins. In some embodiments, when the analyte binds to the indicator compound, the indicator compound undergoes a conformational change. In some embodiments, the conformational change results in a luminescent signal that allows quantification of the amount of analyte present.

Indicator compounds, devices comprising indicator compounds, and methods of making and using the same

An optical measurement device includes a light source, a first detector, and a second detector. The light source emits light to a measurement site of a patient and one or more detectors detect the light from the light source. At least a portion of a detector is translucent and the light passes through the translucent portion prior to reaching the measurement site. A detector receives the light after attenuation and/or reflection or refraction by the measurement site. A processor determines a light intensity of the light source, a light intensity through a tissue site, or a light intensity of reflected or refracted light based on light detected by the one or more detectors. The processor can estimate a concentration of an analyte at the measurement site or an absorption or reflection at the measurement site.

Methods and devices for detecting intensity of light with translucent detector

Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from essentially the same, overlapping, or proximate regions of tissue of a patient are disclosed. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus and can be oriented such that each sensor is directed towards, or can obtain a measurement from, the same or a similar location.

Non-invasive medical monitoring device for blood analyte measurements

The present disclosure describes example systems, methods, apparatuses, and medical devices for obtaining physiological parameter data from a wearable patient monitoring device. An example patient monitoring device can include an emitter and a detector. The emitter can emit light through tissue of a patient. The detector can sense the light after it passes through and is attenuated by the tissue and can generate a signal indicative of the sensed light. When the patient monitoring device is attached to or worn by the patient, the emitter and detector are aligned such that the light from the emitter travels through an opening between a first bone and a second bone of the patient prior to being sensed by the detector.

Growing community of inventors

Lake Forest, CA, United States of America

Kevin Hughes Pauley