The Brigham and Women's Hospital, Inc.

Kevin Ho

Steven C Hebert

This invention is directed to the cloning of the gene which encodes an ATP-sensitive K.sup.+ channel in rat outer medulla cells, isolated cDNA sequences which encode said ATP-sensitive K.sup.+ channels, isolated proteins produced by said cDNA sequences, and agents capable of binding to said proteins. Further included in the invention are methods for identifying other members of the family of ATP-sensitive potassium channels (the ROMK1 family of channel proteins), identifying, isolating, and cloning the genes which encode ROMK1 associated polypeptides, identifying agents capable of binding to other members of the family, modulating expression of said family of ATP-sensitive potassium channels, and modulating the activity of said family of ATP-sensitive potassium channels. Additionally, included in the invention are methods for identifying drugs which function as K.sub.ATP channel openers and K.sub.ATP channel closers.

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Newton, MA, United States of America

Kevin Ho