Pacific Biosciences of California, Inc.

Ciena Corporation

Kevin Hester

Patrick Marks

David J Holden

Austin B Tomaney

Kenneth Mark Maxham

Devon Murphy

Stephen Wilson Turner

Paul M Lundquist

Cheng Frank Zhong

Joy Roy

John Dixon

Hovig Bayandorian

Peiqian Zhao

Yanqiao Huang

Chris Kennedy

Carlos Henriquez

Yujuan Cheng

Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.

Methods and processes for calling bases in sequence by incorporation methods

This invention provides systems for analyzing substrates. Also provided by the invention are improved optical systems for enhanced multiplex illumination, optical systems with compact multi-wavelength illumination architectures, optical systems for enhanced detection of optical signals, and optical systems for reduced autofluorescence background noise.

Substrate analysis systems

A clock and data recovery (CDR) system that generates one or more clock signals from a received data stream and determines an optimal clock signal to associate with the incoming data stream. The system includes a candidate clock generation circuit that operates to receive the incoming data stream and generate candidate clock signals. A transition density detector circuit determines a transition density parameter associated with each of the candidate clock signals. A controller operates to determine the optimal clock signal based on the transition density parameters.

System for clock and data recovery

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Belmont, CA, United States of America

Kevin Hester