Applera Corporation

Applied Biosystems, LLC

Kevin Hennessy

Karl J Guegler

Kenneth J Livak

Aldrich N K Lau

David Ruff

Michael Harrold

Mark Shannon

Kai Qin Lao

Caifu Chen

Sean Matthew Desmond

Paul O Ramstad

Teodoro Paner

Vinod Mirchandani

The present teachings provide methods, compositions, and kits for detecting the presence of protein aggregates. In some embodiments, the protein aggregate is treated with a labeled precursor, and the labeled precursor is incorporated into the protein aggregate to form a labeled protein aggregate. The labeled protein aggregate is then measured, thus detecting the presence of the protein aggregate. In some embodiments, the labeled protein aggregate is detected by interaction of labeled precursors, for example by a proximity ligation assay.

Methods, compositions, and kits for detecting protein aggregates

The present invention provides products and methods of reducing dye artifacts from chain extension reactions.

Products and methods for reducing dye artifacts

The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures.

Concatameric ligation products: compositions, methods and kits for same

Devices are provided which include supports upon which one or more ion-exchange materials can be disposed for purifying a sample. In various embodiments, the supports include a plurality of deformable members, for example, petal-shaped purification members, that provide binding sites for ion-exchange material and optionally biochemical species, chemicals, salts, or other materials. An apparatus and method are also provided for the insertion and removal of the purification members into respective wells of a multi-well microplate.

Petal-array support for use with microplates

Growing community of inventors

San Mateo, CA, United States of America

Kevin Hennessy