Vium, Inc.

Other

Kevin Harada

Jonathan Betts-Lacroix

Laura R Schaevitz

Kyle Howard Heath

Alexander Izvorski

Joe Betts-Lacroix

Alson Kemp

Alexander Izvorksi

Gordon Bryce Jensen

An animal exercise device is described in the form a rotating wheel, generally cylindrical in form, open on one face for an animal to enter and exit, and solidly closed on the other face, which also provides a bearing for rotation. The wall and closed face are solid to avoid injury to an animal. The wheel's axis of rotation is at an angle from horizontal. The inside surface of the wall comprises spaced ridges for gripping by the animal's toes or feet. A contrasting marking on the outside surface of the wall aids vision-based rotation measurement. Embodiments are supported solely through the bearing and have no rotation drive other than use by an animal. Methods of use include automated measurement, using equipment external to the cage, of animal health and use in a multihoused cage where unique animal ID is associated with wheel use.

Animal exercise wheel

A cage for housing at least one experimental animal is disclosed. The cage may include one or more walls that enclose a living space for at least one experimental animal with at least one wall comprising a plastic material. At least one electrical feedthrough may traverse the wall. The electrical feedthrough may include an internal electrical contact located inside the living space and an external electrical contact located outside the living space. The internal and external electrical contacts may be electrically connected. A system for monitoring at least one experimental animal and an electrical feedthrough for providing electrical continuity through a wall of a cage for housing an experimental animal is also disclosed.

Feedthrough electrical connection, and experimental animal cages and monitoring systems including the same

A wireless, sterilizable scale comprising an upper module, on which an animal sits or explores, and a lower module that measures the weight of the animal. The lower module comprises a flexible membrane, through which the weight of the upper module and the animal is mechanically coupled. The flexible membrane is affixed at its perimeter to the perimeter of the lower module. The lower module is sealed by the membrane and comprises a load cell, batteries and electronics. The upper module removes easily from the lower module leaving the lower module intact and sealed for chemical sterilization. Electronics in the upper module connects to electronics in the lower module via an electrical connector that also penetrates the flexible membrane. IR communications from the upper modules transmits a series of weight values at two different data rates. The scale may be in a sterile cage free of electrical penetrations.

Sterilizable wireless animal scale

A device and method of keeping litter in an animal cage away from equipment in an animal cage. Embodiments comprise two or more walls to define three zones in an animal cage: an equipment zone, a channel zone, and an outsize zone. The channel zone connects the outside zone with the equipment zone. Baffles in the channel zone permit access by animals but block some fraction of litter from passing from the outsize zone into the equipment zone. Embodiments include a weighing scale in the equipment zone. Embodiments include shapes that constrain devices or equipment to predetermined locations within a cage. Embodiments include methods of use and use in a vivarium.

Device and method of restricting animal litter movement

A communicating sterile scale is described suitable for automated use in animal cages. An upper module provides a weighing platform, electronics, upward facing wireless communication elements, a protecting skirt, and interface to a combined weight-bearing and electrical penetration element. A lower module provides a case, internal electronics, load cell, power source, sterile-sealed flexible complaint membrane and a combined weight bearing and electrical penetration element through the membrane. The upper and lower modules are easily separable for sterilization by immersion in a sterilizing fluid. The power source in the case may be charged through same electrical penetrating element. The membrane comprises a perimeter that is attached and sealed to the case, a penetration area penetrated by the rigid weight-bearing element, and an isolating compliance area. The skirt on upper module protects detritus from entering from below onto the membrane, while providing open-air movement. Upward facing narrow-beam communication elements provide association-free communication protocols.

Communicating scale

An animal cage is described suitable for automated use in a vivarium. The cage comprises a study animal; bedding; pathogens; a wireless, a sterilizable scale comprising a sterile case comprising a flexible, penetrated membrane; and a penetrating fastener penetrating the membrane. The comprises four internal volume areas with respect to pathogen content: (1) volume between the membrane and a weighing platform, free of bedding; (2) a sterile volume inside the scale case below the membrane; (3) a vertical channel fluidly connecting the inside of the cage with the first volume; and (4) the inside of the cage outside of the above three volumes. These four volumes are sterilely isolated from air outside the cage. Electronics in the scale communicate wirelessly, through the cage, to cage-associated electronics outside the cage, using narrow beam communications free of device-ID specific protocol. The scale may be disassembled, sterilized in a fluid, re-assembled, and re-used in a different cage.

Animal cage

A sterile scale is described suitable for automated use in animal cages. A case is covered by a flexible membrane that provides both sealing against pathogens and mechanical compliance for transfer of weight on an above weighing platform through a single sealed penetration in the membrane to a load cell in the case. The membrane comprises a perimeter that is attached and sealed to the case with a membrane frame, a penetration area, penetrated by a rigid weight-bearing element, and an isolating compliance area. A skirt on the weighing platform surrounds the case, protecting detritus from entering from below onto the membrane, while providing open-air movement. The weighing platform and case are easily separated permitting fluid-based sterilization of both. The weight-bearing element may contain an electrical connection from the case to the platform, through the membrane.

Sterilizable animal scale

A doorway interconnection and method of creating an airtight seal between two doorways includes a first temporary membrane creating an airtight seal on a first doorway and a second temporary membrane creating an airtight seal on a second doorway and a gasket between the two doorways, and vents and valves to place and remove a sterilizing fluid in the inter-doorway volume. Such a system may be used to attach a sterile modular building unit to a sterile facility without losing the sterility of either the facility or the module building unit. Access to the membranes may be from one direction only. The gasket may provide motion and sound isolation between. Additional elements limit relative motions between the first and second doorways.

Device, system and method of interconnecting doorways

A wireless, sterilizable scale comprising a moving module, on which an animal sits or explores, and a fixed module that measures the weight of the animal on the moving module. The fixed module comprises a compliant membrane or gasket, through which the weight of the moving modules and animal is mechanically coupled. The fixed module comprises three load cells arranged in a triangle so as to support the moving module, through the membrane, such that its tilt is limited. The fixed module is sealed by the membrane and comprises the load cells, batteries and electronics. The fixed module, including an internal moving platform, may be chemically sterilized. The moving module may be sterilized using heat sterilization. IR communication transmits a series of weight values at two different data rates. The scale may be in a sterile cage free of electrical penetrations. A system comprises a vivarium comprising such cages.

Growing community of inventors

San Mateo, CA, United States of America

Kevin Harada