University of Minnesota

Kevin H Mayo

Thomas R Hoye

Beulah H Gray

Judith R Haseman

Arjan Griffioen

Xuemei Chen

Xuemei Cheri

Carolee Flader-Lavey

Carolee Flader Lavey

A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.

Calixarene-based peptide conformation mimetics, methods of use, and methods of making

Partial peptide mimetics and methods of making and using, wherein the partial peptide mimetics have a first amino acid sequence comprising ANIKLSVQMKL (SEQ ID NO:8), a homolog thereof, or a segment of SEQ ID NO:8 or a homolog thereof, a second amino acid sequence comprising IIVKLND (SEQ ID NO:2), a homolog thereof, or a segment of SEQ ID NO:2 or a homolog thereof, and a &#x3b2;-turn inducing scaffold bonded between the first and second amino acid sequences.

Partial peptide mimetics and methods

Polypeptides and methods of use including treating bacterial infection and/or endotoxemia, decreasing the amount of TNF-&#x3b1;, inhibiting endothelial cell proliferation, inhibiting angiogenic-factor mediated inter-cellular adhesion molecule expression down-regulation, and inhibiting angiogenesis.

Polypeptides with therapeutic activity and methods of use

This invention relates to the chemical design and production of peptides, peptide structure and three dimensional conformation was assessed using NMR, circular dichroisin and pulsed field gradient NMR. In addition, this invention relates to peptides produced by these methods and to methods for using the peptides.

Synthetic approach to designed chemical structures

Synthesis of soluble &bgr;-sheet forming peptides

A method for synthesizing a water-soluble .beta.-sheet forming peptide having at least about 35% amino acids having hydrophobic side chains, the method comprising linking amino acids having charged side chains and amino acids having noncharged polar side chains with amino acids having hydrophobic side chains, wherein the amino acids having charged side chains are provided in a ratio of at least about 2:1 amino acids having positively charged side chains to amino acids having negatively charged side chains; wherein the peptide is water soluble under physiological conditions and forms .beta.-sheet structures.

Method for synthesizing a water-soluble .beta.-sheet forming peptide

The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are preferably about 10 to 100 amino acids long and have bactericidal and/or endotoxin neutralizing activity. The peptides can be prepared by automated protein synthesis or by recombinant DNA methods. The peptides are useful in methods to treat and prevent bacterial infection in the body and on surfaces. The peptides are also useful to treat endotoxin shock and have endotoxin neutralizing activity.

Peptides with bactericidal activity and endotoxin neutralizing activity

The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are about 10 to 100 amino acids long and have bactericidal and/or endotoxin neutralizing activity. The peptides can be prepared by automated DNA synthesis or by recombinant DNA methods. The peptides are useful in methods to treat and prevent bacterial infection in the body and on surfaces. The peptides are also useful to treat endotoxin shock.

Growing community of inventors

Minneapolis, MN, United States of America

Kevin H Mayo