Vertex Pharmaceuticals, Inc.

Other

Cisco Technology, Inc.

Kevin Gagnon

Ales Medek

Yi Shi

Muna Shrestha

Michael Aaron Brodney

John Patrick Maxwell

Dennis James Hurley

Qing Tang

Kevin Michael Cottrell

Upul Keerthi Bandarage

Jinwang Xu

Simon Giroux

Adam R Looker

Michael John Boyd

Ronald Lee Grey, Jr

Stephen Andrew Thomson

Stefanie Roeper

Lev Tyler Dewey Fanning

Michael Waldo

Mac Arthur Johnson, Jr

Peter D Jones

Philippe Marcel Nuhant

Diane M Boucher

Brad D Maxwell

Amy Beth Hall

Rebecca Jane Swett

Timothy Lewis Tapley

Cavan McKeon Bligh

Setu Roday

Sarathy Kesavan

Robert Francis Fimognari, Jr

Veronique Damagnez

Rupa Sawant

Sarah Carol Hood

Pedro Manuel Garcia Barrantes

Mark Thomas Miller

Jinglan Zhou

Sara Sabina Hadida Ruah

Jason McCartney

Tiansheng Wang

Corey Don Anderson

Steven M Ronkin

Brian Ledford

Jingrong Cao

Peter Grootenhuis

Jon H Come

Beili Zhang

Thomas Cleveland

Bryan A Frieman

Timothy Richard Coon

Prasuna Paraselli

Fabrice Pierre

Jeremy J Clemens

Michael P Clark

Suganthini S Nanthakumar

Kathy Stavropoulos

Peter Jamison Rose

Warren A Dorsch

Elaine B Krueger

Sara E Swift

Leslie A Dakin

Timothy J Senter

Carl Zwicker

Kirk Overhoff

Anne Fortier

Olivier Nicolas

Camil Sayegh

Mariam Zaky

Jennifer Lu

Jicong Li

Mei-Hsiu Lai

Marisa Sposato

Siying Liu

Gabrielle Simone Fleming

Robert Daniel Giacometti

Samantha Guido

Martine Hamel

Francois Denis

Kan-Nian Hu

Faith Witkos

Jean-Philippe Vasseur

Grégory Mermoud

Pierre-André Savalle

Victor H Goulter

Mettachit Navamal

Mary Elizabeth Eccles

Joshua Kennedy Hussey

The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Modulators of alpha-1 antitrypsin

Crystalline forms of Compound I: pharmaceutically acceptable salts thereof, and solvates and hydrates thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Crystalline forms of CFTR modulators

The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).

Inhibitors of APOL1 and methods of using same

Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

The disclosure provides a compound of Formula (I), including deuterated derivatives, pharmaceutically acceptable salts, and solvates thereof, solid state forms of those compounds, compositions comprising those compounds and solid forms, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD). 

In one embodiment, a device receives traffic telemetry data captured by a plurality of networks and used by device classification services in the networks to classify endpoints in the networks with device types. The device compares the telemetry data from a particular one of the networks to the telemetry data from the other networks to identify one or more traffic characteristics that are missing from the telemetry data for one or more endpoints of the particular network. The device identifies a networking entity in the particular network that is common to the one or more endpoints for which the one or more characteristics are missing. The device determines a configuration change for the networking entity by comparing a current configuration of the entity to those of one or more entities in the other networks. The device initiates implementation of the determined configuration change for the entity in the particular network.

Closed loop control for fixing network configuration issues to aid in device classification

A cooling system for cooling electrical components in a personal computer is provided. The cooling system provides filtered air under a positive air pressure to such components in the computer, as the electrical power supply and microprocessor, as well as other components in the computer. The filtered air cools the components and prevents dust from collecting on the components. In a second embodiment, the cooling system includes a tower style case for supporting the personal computer. The case houses an air filter and induction fans, for providing copious cooling air flow through ducts in the computer. Air vents are placed in optimal areas in the computer, such as near the microprocessor and power supply, to provide increased air circulation for the components in these areas. A switch panel is additionally provided that enables energizing peripheral devices when desired.

Dual filtered airflow systems for cooling computer components, with

A reusable wire mesh sleeve for removably mounting upon a drive spindle and being rotatable therewith. A roll of waste material forms on the rotating sleeve which may then be removed from the spindle. The sleeve is flexible such that it collapses upon itself when removed from the spindle whereby it is easily removable from the roll. The roll is then discarded minus a core which helps to reduce the amount of waste entering the landfill and/or incinerator. The sleeve is extremely durable such that it may be re-used indefinitely.

Reusable waste matrix sleeve

Growing community of inventors

Burlington, MA, United States of America

Kevin Gagnon