Other

Pfizer Corporation

Amgen Fremont Inc.

Kevin G Coleman

Larry L Green

Xiao-Chi Jia

Vahe Bedian

Shama Kajiji

Neil R Michaud

Gary Borzillo

Bernard N Lipscher

Michael S Yurkovic

Earl H Bickett

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

Treatment methods using c-Met antibodies

Antibodies to c-Met

The invention relates to a combined portable scoring system and storage/carrier unit. There is disclosed a portable storage/carrier unit which is intended to be used for storing and carrying sporting equipment of any type when used or not used for scoring a game. Upon arrival at a game site, the equipment and first-aid supplies are removed as needed from the storage/carrier unit, closed and placed in an upright position. The storage/carrier unit includes a plurality of pockets formed in the outer planar surface of at least one side of the unit by a plurality of continuous tracks and accommodates scoring number packets, home team and guest team names as well as a sponsor's name. A centrally located rotary pointer dial is provided to indicate the inning or quarter of play. An out indicator is provided as well. Upon completion of the game or games, the scoring numbers, inning/out indicator, team names and sponsor names are removed from their respective positions and along with sporting equipment and first-aid supplies are stowed within the storage/carrier unit. The scoring system can be used for a variety of different games.

Combined portable scoring system and storage/carrier unit

A computer security system employs a first telephone line for controlling a security unit which connects a second telephone line to the computer. Each authorized user must have a user security unit generating a control signal, such as an audio signal modulated by a pulse signal having a selectable pulse frequency, pulse duration and/or duration between pulses.

Computer security system

A door message apparatus has a control unit which responds to operation of a doorbell switch to connect a door speaker/microphone to an automatic telephone answering and recording machine. The control unit applies a ring signal to the answering machine so that the machine then plays back a prerecorded message which is broadcast to the door caller. After the playback, the door caller may talk into the door speaker/microphone to produce a message which is recorded by the answering machine.

Door message apparatus with telephone answering device

An alarm system for an electric range which detects when a burner is energized without a utensil in place on the burner wherein the sensing means comprises an electrical switch mounted below the stovetop having a first switch position and a second switch position, a pin slidably passing through an opening in the stovetop beneath the rim of the dish under the heating element in contact with the underside of the rim and biased against the rim with a pressure sufficient to lift the rim from the stovetop when no utensil is present on the heating element, but insufficient to lift the rim when a utensil is in place on the heating element; and means connecting said pin with the switch to operate the switch between first and second positions corresponding to the position of the pin when a utensil is present or absent from the heating element.

Growing community of inventors

Old Lyme, CT, United States of America

Kevin G Coleman