City of Hope

Kevin Ferreri

Mohamed I Husseiny Elsayed

Qiang Liu

Yun Yen

Steve S Sommer

Fouad Kandeel

Rasha Shehatta

Provided herein are, inter alia, nucleic acids, methods, and kits for detecting unmethylated DNA in body fluid sample of a subject. The disclosure includes compositions, methods, and kits for detecting unmethylation at a CpG site in an insulin gene promoter of a subject.

Methods and compositions for measuring beta cell death

Provided herein are attenuatedbacteria for expressing autoantigen alone or in combination with an immunomodulatory, as well as methods of using these bacteria to treat various autoimmune disorders.

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The present invention provides a method for detecting transplantation failure of a transplanted organ or cells which comprises detecting a donor-positive but recipient-negative DNA marker in the recipient's plasma using pyrophosphorolysis activated polymerization. Because of the high sensitivity, specificity and selectivity of pyrophosphorolysis activated polymerization, transplantation failure can be detected at early stages and treatment can be initiate earlier.

Ultra-high sensitive monitoring of early transplantation failure

Provided herein are attenuatedbacteria for expressing autoantigen alone or in combination with an immunomodulator, as well as methods of using these bacteria to treat various autoimmune disorders.

Growing community of inventors

Culver City, CA, United States of America

Kevin Ferreri