Araceli Biosciences, Inc.

Kevin Ferguson

Luke Ternes

Methods and systems are provided herein for automatic object classification. In an example, a method includes receiving one or more images of a plate including a plurality of wells, each well including a plurality of cells, the plurality of wells including a first control well, a second control well, and at least one test well, classifying one or more cells from the at least one test well using a trained classification model, the trained classification model trained based on training data including instance images of the first control well and the second control well formed from the one or more images of the plate and further based on an effect size loss function, and outputting an indication of the classified one or more cells.

Systems and methods for effect size optimization of object classification

Methods and system are provided herein for crosstalk mitigation, such as the removal of crosstalk interference from a microscopy image signal to recover an intended image from the image signal. In one example, a method includes accumulating a plurality of weighting constant values and variance data to determine a weighting constant of a weighted interference signal of a microscopy image, wherein determining the weighting constant comprises fitting the plurality of weighting constant values and variance data to a quadratic curve; determining the weighted interference signal of the microscopy image based on the weight constant; removing the weighted interference signal from an overall image signal of the microscopy image; and determining a recovered image signal based on removal of the weighted interference signal from the overall image signal.

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Beaverton, OR, United States of America

Kevin Ferguson