University of California

Northwestern University

B. Braun Medical Inc.

The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David Gladstone

Other

Bioengineered Materials, Inc.

Kevin Edward Healy

David V Schaffer

Samuel Thomas Wall

Amit Kumar Jha

Krishanu Saha

Wesley M Jackson

Mark B Ratcliffe

Eda Isil Altiok

Julius Guccione

Gary S Dorfman

Patrick Sean Daugherty

Bruce Conklin

Joseph T Walsh, Jr

Nathaniel Huebsch

Peter Loskill

Lauren Little

Jane P Bearinger

Luke P Lee

Phillip B Messersmith

Andrew Boyle

Andreas Stahl

Yerem Yeghiazarians

Anurag Mathur

Kyumin Whang

Soongweon Hong

Kevin Tharp

Judith Kraiczy

Carson H Thomas

Jianqin Ye

Willie Mae Reese

Christine F Wildsoet

James Su

Patrick Burch

Ranee A Stile

The invention relates to devices, methods, kits, and compositions for in vitro generation of three-dimensional micro-tissues that are accurate models of heart, skeletal muscle, neuronal, and other tissues.

Reversible stencils for fabricating micro-tissues

The present disclosure provides methods of treating an ocular disease or disorder. The methods involve direct administration into the eye of a conjugate comprising a biologically active polypeptide and a biocompatible polymer.

Methods of treating an ocular disease or disorder

The present invention provides polypeptide-polymer conjugates. A subject polypeptide-polymer conjugate is useful in a variety of applications, which are also provided.

Polypeptide-polymer conjugates and methods of use thereof

The disclosure provides for coating compositions comprising macrocycles and salts in aqueous buffer and the use of the coating composition to prevent absorption of small molecules into polymeric surfaces.

Macrocyclic polyphenols for universal coatings

The present invention provides materials and methods that can serve as a prosthetic and/or, for tissue engineering applications, as a supporting matrix in the stabilization of an injured or defective myocardial wall in a patient comprising injecting a polymer network at a pre-selected site in the myocardial wall of the patient.

Methods and compositions for stabilizing the myocardium

The present disclosure provides a microfluidics device for culturing cells, such as cardiomyocytes or cardiomyocyte progenitors; and methods of culturing cells using the device. The device and culturing methods find use in drug screening methods, for methods of evaluating a drug under development, and for methods of predicting patient response to a given treatment regimen, which methods are also provided.

Microfluidics cell culture device

The present disclosure provides compositions comprising a hydrogel and a cell adhesion ligand that enhances the differentiation of mesenchymal stem cells into brown adipocytes, and/or enhances the maintenance of brown adipocytes. In some cases, a subject composition includes cells that are embedded within the hydrogel. The present disclosure also provides methods of making and using the subject compositions.

Compositions and methods for producing and administering brown adipocytes

The present disclosure provides methods for sulfonation of hyaluronic acid. The present disclosure provides sulfonated hyaluronic acid, and compositions, including pharmaceutical compositions, comprising the sulfonated hyaluronic acid. The present disclosure provides implantable materials and drug delivery compositions comprising a subject sulfonated hyaluronic acid.

Ethylsulfonated hyaluronic acid biopolymers and methods of use thereof

Provided herein are hydrogel cell matrices, hydrogel cell matrix systems for the support, growth, and differentiation of a stem cell or progenitor cell and methods for making such hydrogel cell matrices.

Growth factor sequestering and presenting hydrogels

Provided herein are compositions and methods for isolating and culturing cardiac progenitor cells, and for improved transplantation.

Cardiosphere derived cell population and methods of use

Growing community of inventors

Moraga, CA, United States of America

Kevin Edward Healy