Pfizer Corporation

Other

Pfizer Products Inc.

Kevin Daniel Freeman-Cook

Sacha Ninkovic

Robert Louis Hoffman

Asako Nagata

Douglas Carl Behenna

Samit Kumar Bhattacharya

Michael Luzzio

Matthew Merrill Hayward

Jun Xiao

Christopher Lowell Autry

Kendra Louise Nelson

Xumiao Zhao

Catherine Angela Hulford

Cynthia Louise Palmer

Sajiv Krishnan Nair

Scott Channing Sutton

Eugene Yuanjin Rui

Mehran Jalaie

Ping Chen

Mark Carl Noe

Martha Alicia Ornelas

David Andrew Griffith

Robert Steven Kania

Dennis Paul Phillion

Kimberly O Cameron

Lawrence Alan Reiter

Liying Zhang

John M Curto

Martin Youngjin Pettersson

Richard Louis Elliott

Jeffrey W Corbett

Matthew Forrest Sammons

Qingyi Yang

Yajing Lian

Jeffrey Wayne Corbett

This invention relates to compounds of Formula (I)

CDK2 inhibitors

This invention relates to compounds of Formula (I) and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein R, Rand Rare as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

This invention relates to compounds of general Formula (I) 

CDK2/4/6 inhibitors

This invention relates to compounds of general Formula I in which A, R, R, Rand Rare as defined herein, and the pharmaceutically acceptable salts thereof; to pharmaceutical compositions comprising such compounds and salts; to methods of using such compounds, salts and compositions for treating pulmonary hypertension and related diseases, like pulmonary arterial hypertension; to methods of using such compounds, salts and compositions for treating abnormal cell growth, such as cancer; and to processes to make such compounds, salts and compositions.

Anti-proliferative agents for treating PAH

This invention relates to compounds of Formula (I) 

The present invention relates to a compound of the formula I wherein Rto R, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Sulfonyl amide derivatives for the treatment of abnormal cell growth

The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R, R, and Rare as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of acetyl-CoA carboxylase enzyme(s) in an animal. 

Pyrazolospiroketone acetyl-CoA carboxylase inhibitors

The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formulawherein X, A, Y, B, G, W, and Rare as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors

The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formulawherein said ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, G, and W are as defined in the specification; and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

Triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors

The present invention relates to N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formulawherein ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, and G are as defined in the specification; and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors

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Clinton, CT, United States of America

Kevin Daniel Freeman-Cook