Washington State University

Kevin D Walker

Rodney Bruce Croteau

Mark R Wildung

Anne Schoendorf

Transacylase enzymes and the use of such enzymes to produce paclitaxel, related taxoids, as well as intermediates in the paclitaxel biosynthetic pathway are disclosed. Also disclosed are nucleic acid sequences encoding the transacylase enzymes.

Transacylases of the paclitaxel biosynthetic pathway

Transacylase enzymes of and the use of such enzymes to produce Taxol&trade;, related taxoids, as well as intermediates in the Taxol&trade; biosynthetic pathway are disclosed. Examples of specific enzymes described herein include taxadienol 5-O-acetyl transacylase (TAX1) and 10-deacetylbaccatin III-10-O-acetyl transferase (TAX6). Also disclosed are nucleic acid sequences encoding the transacylase enzymes.

Nucleic acid molecules encoding 10-deacetylbaccatin III-O-acetyl transferase and related products

Transacylase enzymes and the use of such enzymes to produce Taxol&trade;, related taxoids, as well as intermediates in the Taxol&trade; biosynthetic pathway are disclosed. Also disclosed are nucleic acid sequences encoding the transacylase enzymes.

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Pullman, WA, United States of America

Kevin D Walker