University of South Florida

Kevin D Revell

Edward Turos

Rajesh Kumar Mishra

Cristina M Coates

The present invention provides N-alkylthio &#x3b2;-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and methods of their use as anti-bacterial agents.

N-alkylthio beta-lactams, alkyl-coenzyme A asymmetric disulfides, and aryl-alkyl disulfides as anti-bacterial agents

[object Object]

The present invention provides N-alkylthio &#x3b2;-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and method of their use as anti-bacterial agents.

Asymmetric disulfides and aryl-alkyl disulfides as anti-bacterial agents

This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, including bacteriostatic properties againstspp., including methicillin resistant(MRSA), andspp., including

Growing community of inventors

Murray, KY, United States of America

Kevin D Revell