University of Texas System

Tissuegen, Inc.

Ethicon, Gmbh

Ball Semiconductor Corporation

Kevin D Nelson

Brent B Crow

Zhibing Hu

Andres A Romero-Sanchez

George M Smith

Nadir Alikacem

Delia Radulescu

Paula Waggoner

Nickolas B Griffin

Paul R Sood

Alpeshkumar P Patel

Jennifer Seifert

Paul A Hubbard

Jeffrey Mendel Gross

Akira Ishikawa

Lev Drubetsky

Alexander Naimagon

Nabuo Takeda

Suzanne I Ahn

Steven R Hays

William L D'Agostino

Rui Avelar

Paula J Taylor

A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect.

Methods and compositions for maintaining the conformation and structural integrity of biomolecules

A drug-eluting self-retaining suture comprises a filament, a plurality of retainers, and a drug impregnated in or coated on the filament. The shape and distribution of retainers modifies the in vivo release kinetics of the drug. The drug release kinetics may be modified uniformly or region by region. The self-retaining suture may for example be used for reattaching severed nerves and release nerve growth factor or other regeneration accelerating agents into the region of the nerve injury.

Drug-eluting self-retaining sutures and methods relating thereto

The invention relates to a helical coil comprising multiple reversing sense helical coil units that are capable of drug elution, come in lengths appropriate for long, diffuse lesions, have the ability to have a step-wise tapering diameter, and provide all the benefits of a small closed cell stent design while maintaining high flexibility, high radial force and crush resistance due to an underlying helical coil.

Self-expanding medical device

The present invention relates to fiber compositions comprising gels or hydrogels. The invention further relates to the composition of a gel or hydrogel loaded biodegradable fiber and methods of fabricating such fibers. The present invention further provides tissue engineering and drug-delivery compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The invention also relates to methods of manipulating the rate of therapeutic agent release by changing both the biodegradable polymer properties as well as altering the properties of the incorporated gel or hydrogel.

Drug releasing biodegradable fiber for delivery of therapeutics

The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.

Fabrication of drug loaded biodegradable polymer fibers

Drug releasing biodegradable fiber implant

A biochemical sensor based on ball integrated circuit technology which is designed to be biocompatible for implantation within a human or animal body. A sensor media is mounted to the ball integrated circuit, the sensor media operable for sensing biochemical molecules. An onboard communication link transmits data sensed by the sensor media from the ball integrated circuit.

Glucose sensor

Growing community of inventors

Arlington, TX, United States of America

Kevin D Nelson