Merck Sharp + Dohme Corp.

Merck Sharpe & Dohme Corp.

Sbi Incubation Co., Ltd.

Kevin Caili Wang

Pingyu Zhong

Yan Li

Peter Peizhi Luo

Feng Dong

Rose M Cubbon

Laurence B Peterson

Holly A Hammond

Jeffrey T Blue

Ayesha Sitlani

Jon H Condra

Shilpa Pandit

Denise K Nawrocki

Joseph C Santoro

Sonia M Gregory

Dana D Wood

Henryk Mach

Mark Hsieh

Timothy McCabe

Heidi Pixley

Peizhi (Peter) Luo

Laura Orsatti

Heidi Yoder

Andrei Alexandrovich Golosov

Xinwei Wang

Weirong Wang

Chikao Morimoto

Yan Ni

Jian Wang

Teikichi Aoyagi

Timothy Mccabe

Antagonists of human proprotein convertase subtilisin-kexin type 9 ('PCSK9') are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.

1B20 PCSK9 antagonists

AX1 PCSK9 antagonists

1D05 PCSK9 antagonists

The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.

Eukaryotic cell display systems

The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.

Anti-CD26 antibodies and methods of use thereof

Growing community of inventors

Lansdale, PA, United States of America

Kevin Caili Wang