Big Horn Valve, Inc.

The Texas A&M University System

Other

Mcgill University

Small Molecule Ppi Mimics LLC

Kevin Burgess

David J Yakos

Bryan Walthall

Ross Forrest Walker

Richard Gibbs

Syed Muhammad Usama

Daniel E Clawson

Horacio Uri Saragovi

The present disclosure provides conjugates of kinase inhibitors and cyanine dyes, as well as related compositions, methods and uses.

Conjugates of kinase inhibitors and cyanine dyes

Compounds that disrupt the interaction between PCSK9 and LDLR, compositions that include the compounds, and methods for making and using the compounds and compositions.

Inhibitors of LDLR-PCSK9 protein-protein interaction and methods of their use

A rising stem valve with a magnetic actuator having an outer and as inner magnet assembly that are magnetically coupled to each other so that the inner and outer magnet assemblies rotate together and a ball screw that is connected to the rising stem valve and that converts rotary to reciprocal motion. The inner magnetic cartridge assembly and valve body comprise a sealed lower section that is completely sealed to the outside environment.

Leak-free rising stem valve with ball screw actuator

Monovalent compounds having moieties comprising at least one amino acid side chain are bound to a core molecule, which also comprises a nucleophilic moiety bound to said core molecule. Monovalent compounds also comprise a macrocyclic ring, a nucleophilic moiety, and a spacer group. Monovalent compounds may be combined into bivalent and trivalent compounds, some of which may have a labeling tag. Methods of production of bivalent compounds and contemplated uses thereof are disclosed.

Dipeptide mimics, libraries combining two dipeptide mimics with a third group, and methods for production thereof

A rotary valve assembly composing a leak-free enclosure containing a worm gear and a pinion gear, an adapter plate that is situated between a rotary valve body and the enclosure and that secures the rotary valve body to the enclosure, and a magnetic actuator assembly. The worm gear engages with the pinion gear such that when the worm gear rotates, the pinion gear rotates as well. The enclosure is situated between the magnetic actuator assembly and the rotary valve body. A shaft extends through the center of the pinion gear and causes a valve within the rotary valve body to open and close based on rotation of the shaft. In an alternate embodiment, the invention is a rotary valve as described above with an integral adapter plate.

Leak-free rotary valve with internal worm gear

A valve assembly comprising an adapter plate assembly comprising an adapter plate, a bonnet with a center and a threaded shaft extending through the center of the bonnet; an actuation assembly comprising an outer enclosure and an outer magnetic cartridge that is magnetically coupled to an inner magnetic cartridge; and an inner valve assembly comprising an inner enclosure and a planetary gear subassembly comprising one or more planetary gears.

Leak-free reciprocating stemmed valve

A stemless ball valve comprising a first flange, second flange, ball, inner magnetic cartridge, outer magnetic cartridge, and planetary gear assembly. The inner magnetic cartridge is situated inside of the outer magnetic cartridge, and the inner and outer magnetic cartridges actuate the valve. The planetary gear assembly is situated between the inner magnetic cartridge and the ball. The planetary gear assembly comprises one or more planetary gear phases, each planetary gear phase comprising a step-down gear. Each planetary gear phase comprises one or more planetary gears that engage with the inner teeth of the outer ring of the planetary gear assembly and with a step-down gear. The invention further comprises a pressure equalization system comprising inner and outer equalization tubes, a piston situated between the inner and outer equalization tubes, and either a piston spring or spring washer stack that biases the piston in the direction of the clean oil.

Planetary gear ball valve

A stemless ball valve comprising a first flange, second flange, ball, inner magnetic cartridge, outer magnetic cartridge, and planetary gear assembly. The inner magnetic cartridge is situated inside of the outer magnetic cartridge, and the inner and outer magnetic cartridges actuate the valve. The planetary gear assembly is situated between the inner magnetic cartridge and the ball. The planetary gear assembly comprises one or more planetary gear phases, each planetary gear phase comprising a step-down gear. Each planetary gear phase comprises one or more planetary gears that engage with the inner teeth of the outer ring of the planetary gear assembly and with a step-down gear.

Planetary gear valve

A stemless ball valve comprising: a right flange; left flange; ball with an axis pin and two travel pins; ball seal on either side of the ball; guide sleeve with inner walls comprising two channels; cartridge guide holder; inner magnetic cartridge; and outer magnetic cartridge. The ball is situated inside of the guide sleeve, and a travel pin is located in each of the two channels. The guide sleeve is situated inside of the cartridge guide holder, which is located adjacent to and outside of the inner magnetic cartridge and secured to the inner magnetic cartridge such that when the inner magnetic cartridge rotates, the cartridge guide holder also rotates. The cartridge guide holder is secured to the guide sleeve such that when the cartridge guide holder rotates, the travel pins move within the channels in the inner walls of the guide sleeve, thereby causing the ball to rotate.

Stemless ball valve

A stemless ball valve comprising two flanges and a ball with a channel, two axis pins and two travel pins. One end of each axis and travel pin is fixedly attached to the ball, and the other end of each axis pin is lodged into a notch in the first or second flange such that the axis pin is allowed to rotate in the notch. The guide sleeve comprises two channels, and one end of each travel pin is situated within one of the two channels in the guide sleeve. An outer magnetic cartridge causes the inner magnetic cartridge and guide sleeve to rotate, and when the guide sleeve rotates, the travel pins move up and down within the channels in the guide sleeve. The movement of the travel pins within the channels in the guide sleeve causes the ball to rotate, thereby opening and closing the ball valve.

A TBET cassette including at least one xanthine- or pyronin-based compound as a donor or acceptor is disclosed. Also, a method of TBET cassette design in which four criteria may be used is provided. TBET cassettes may be used to label biological molecules, in clothing dyes, and in cosmetics.

Fluorescent through-bond energy transfer cassettes based on xanthine and pyronin derivatives

Proteolytically stable small molecule &#x3b2;-turn peptidomimetic compounds have been identified as agonists or antagonists of neurotrophin receptors, such as TrkA. A compound of particular interest binds the immunoglobulin-like C2 region of the extracellular domain of TrkA, competes the binding of another TrkA ligand, affords selective trophic protection to TrkA-expressing cell lines and neuronal primary cultures, and induces the differentiation of primary neuronal cultures. The small &#x3b2;-turn peptidomimetic compounds of the invention can activate a tyrosine kinase neurotrophin receptor that normally binds a relatively large protein ligand. Such compounds that bind the extracellular domain of Trk receptors are useful pharmacological agents to address disorders where Trk receptors play a role, by targeting populations selectively.

&#x3b2;-turn peptidomimetic cyclic compounds

Ligands for chiral catalysis

Fluorescent energy transfer cassettes that allow through bond energy transfer and have a succinimidyl ester functionality suitable for affecting them to biomolecules or provided and are applied to high throughput DNA sequencing.

Growing community of inventors

Bryan, TX, United States of America

Kevin Burgess