Oxford Biomedica (UK) Limited

Oxford Biomedica, Inc.

Kevin Alan Myers

Miles William Carroll

Christopher Robert Bebbington

Fiona Margaret Ellard

Susan Mary Kingsman

Alan John Kingsman

Susan Marie Kingsman

Noel Drury

Abigail Lamikanra

Miles William Carrol

A vector comprising a nucleotide sequence of interest ('NOI') encoding a product of interest ('POI') is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.

Vector

The present invention provides 5T4 tumour-associated antigen (TAA) for use in a method of immunotherapy of tumours. The invention also relates to a recombinant poxvirus vector from which at least one immune evasion gene has been deleted, which comprises a nucleic acid sequence encoding a 5T4 TAA and the use thereof in vaccinating against and in treating tumours.

Polypeptide

Canine and feline 5T4 polypeptide sequences and nucleotide sequences encoding them are provided. A vector system comprising a nucleic acid encoding 5T4 and a 5T4-specific agent are also provided.

Feline 5T4 antigen

The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject, where the nucleotide sequence is expressed in vivo to produce said antibody.

Vector system

Vector encoding an antibody that binds 5T4 antigen

The use of an ScFv Ab (ScFv Ab) capable of recognizing a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.

Antibodies

Nucleotide encoding canine 5T4 antigen

The use of an ScFv Ab (ScFv Ab) capable of recognising a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.

Growing community of inventors

Oxford, United Kingdom

Kevin Alan Myers