The Catholic University of Korea Industry-Academic Cooperation Foundation

Keun-Hyung Cho

Mi-La Cho

Min-Jung Park

Seon-Yeong Lee

Dong-Yun Shin

Sung-Hwan Park

Jong-Young Choi

Chul-Woo Yang

Hyeon-Beom Seo

Joo-Yeon Jhun

Jae-yoon Ryu

Se-Young Kim

The present invention relates to a composition for preventing or treating transplantation rejection or a transplantation rejection disease, comprising a novel compound and a calcineurin inhibitor. A co-administration of the present invention 1) reduces the activity of pathogenic Th1 cells or Th17 cells, 2) increases the activity of Treg cells, 3) has an inhibitory effect against side effects, such as tissue damage, occurring in the sole administration thereof, 4) inhibits various pathogenic pathways, 5) inhibits the cell death of inflammatory cells, and 6) increases the activity of mitochondria, in an in vivo or in vitro allogenic model, a transplantation rejection disease model, a skin transplantation model, and a liver-transplanted patient, and thus inhibits transplantation rejection along with mitigating side effects possibly occurring in the administration of a conventional immunosuppressant alone. Thus, the present invention may be used in the field of pharmaceutics relating to transplantation rejection or various immune disorders possibly occurring after transplantation.

Composition for preventing and treating transplant rejection or transplant rejection diseases, comprising novel compound and calcineurin inhibitor

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Seoul, South Korea

Keun-Hyung Cho