Beijing University of Technology

Puretech Lyt, Inc.

Akili Interactive Labs, Inc.

Seaport Therapeutics, Inc.

Ketki Karanam

Natalie Trevaskis

Jamie Simpson

Daniel Kenneth Bonner

Sifei Han

Luojuan Hu

Rishab R Shyam

Tim Quach

Christopher John Hamilton Porter

James Tendai Mutamba

Adam Piper

Matthew Omernick

Eric Elenko

Adam Gazzaley

Walter Edward Martucci

W Edward Martucci

Christopher John Porter

The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.

Lymphatic system-directing lipid prodrugs

The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

Lipid prodrugs of mycophenolic acid and uses thereof

The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

Lipid prodrugs of rapamycin and its analogs and uses thereof

Systems and methods are provided for the implementation of personalized cognitive training. As an example, a processor-implemented method is provided for enhancing cognitive abilities of a user by personalizing cognitive training regimens through difficulty progression. The method includes: performing a cognitive assessment of a user using a set of assessment tasks; estimating a maximal performance of the user related to the set of assessment tasks; determining a performance range based at least in part on the maximal performance of the user; dividing the performance range into a plurality of progress gates, the plurality of progress gates corresponding to a plurality of task difficulty levels; selecting a first progress gate within the performance range; generating a first set of training tasks associated with the first progress gate; and collecting the user's first training responses to the first set of training tasks.

Processor-implemented systems and methods for enhancing cognitive abilities by personalizing cognitive training regimens

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Newton, MA, United States of America

Ketki Karanam