Acic (canada) Inc.

Brantford Chemicals Inc.

Brantford Chemicalss Inc.

Keshava Ks Murthy

Gamini Weeratunga

Khashayar Karimian

Bruno K Radatus

Derek John Norris

Stephen E Horne

Derrick L Clive

Darren Hall

Anand Daljeet

Kanwarpal S Swidhu

Burchat Andrew

Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.

Methods of making ureas and guanidines including, terazosin, prazosin,

A process for making Fluconazole is provided comprising carrying out the following scheme of reaction: ##STR1##

Commercial process for the manufacture of fluconazole and intermediates

Methods of making ureas and guanidines, including terazosin, prazosin,

Methods of making ureas and guanidines, including, terazosin, prazosin,

Process for the production of an improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics, said process comprising in a substantially anhydrous hydroxylic solvent, comprising at least one alkanol solvent having 3-4 carbon atoms, adding anhydrous hydrogen chloride gas to Ranitidine free base wherein said substantially anhydrous hydroxylic solvent has the characteristics that it solubilizes the Ranitidine free base and hydrogen chloride gas, and subsequently recovering the improved form of Form 1 Ranitidine Hydrochloride.

Process for the production of an improved form of form 1 ranitidine

A process from preparing 5-halogenated 2,3-O-cyclocytidine derivatives comprising reacting 2,3-O-cyclocytidine with a halogenating reagent, preferably N-bromosuccinimide, in the presence of an acid such as acetic or trifluoroacetic.

Process for preparing halogenated 2,3-O-cyclocytidine derivatives

A process for the manufacture of Diltiazem or deacetyl-Diltiazem, which comprises the use of MIBK as solvent and NaOH as base.

Method for the manufacture of benzothiazepine

A 5'-halo-2,3'-O-cyclocytidine of Formula I: ##STR1## wherein: X is a bromide, chloride, or iodide; Y is halide, sulfate, acetate, tosyl, mesyl, benzoate, and phosphate; R.sup.1 is hydrogen; and R.sup.2 is a hydroxy protecting group. Pharmaceutical compositions containing the above compounds exhibit antineoplastic activity.

5-halo-2,3'-O-cyclocytidines

Form of form 1 Ranitidine

A process for making Fluconazole comprising the steps of: ##STR1##

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Brantford, Canada

Keshava Ks Murthy