Mesynthes Ltd.

Industrial Research Limited

Meat and Livestock Australia Limited

Keryn Dallas Johnson

Brian Roderick Ward

Barnaby Charles Hough May

Madhusudan Vasudevamurthy

Barnaby Charles May

The present invention pertains to the development of Extracellular Matrix (ECM) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction. In addition, the present invention features methods of isolating ECM scaffolds from mammalian organs, including but not limited to the ruminant forestomach. The invention further features laminated ECM scaffolds containing a polymer positioned between individual ECM sheets. The polymer may optionally contain bioactive molecules to enhance the functionality of the scaffold.

Tissue scaffolds derived from forestomach extracellular matrix

The invention relates to the use of angiogenic crystallin proteins to promote angiogenesis, wound healing and/or endothelial cell migration. Alpha A crystallin and &#x3b2;B2 crystallin have particular application in these methods. The crystallins will usually be in monomeric form. Typically, truncated form(s) of &#x3b2;B2 crystallin protein are utilized as can be prepared by partial hydrolysis of the protein by a protease enzyme such as elastase I. Methods for the purification of crystallin proteins from eye tissue are also described.

Agents with angiogenic and wound healing activity

Growing community of inventors

Wellington, New Zealand

Keryn Dallas Johnson