Hexima Limited

Kerry Michelle Dunse

Marilyn Anne Anderson

Robyn Louise Heath

The present invention relates generally to a novel chymotrypsin that exhibits resistance to a plant serine proteinase inhibitor. More particularly, the present invention provides a chymotrypsin which is up-regulated in the gut ofandinsect larvae when fed the serine proteinase inhibitors ofThe novel chymotrypsin represents, therefore, a target for the identification of antagonists including inhibitors which are proposed to be useful in the control ofspp. populations that have become resistant to serine proteinase inhibitors produced in plants. The antagonists of the chymotrypsin may be topically applied to the plants or, when in proteinaceous form, may be produced by genetic means in plant cells. The antagonists may act at the level of gene expression or protein activity.

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East Brunswick, Australia

Kerry Michelle Dunse