Nanyang Technological University

Polymedica Industries, Inc.

Kerm Sin Chian

Tze Chiun Lim

David Charlesworth

Christopher John Underwood

Meng Fatt Leong

Fai Kah Leong

The present invention refers to an apparatus and a method for the manufacture of a three-dimensional scaffold at low temperatures and the respective use of this method and apparatus.

Manufacturing three-dimensional scaffolds using electrospinning at low temperatures

The present invention refers to a method of fabricating a three dimensional scaffold suitable for tissue-engineering having a controlled micro- and macroporous structure using cryogenic prototyping. The present invention also refers to scaffolds obtained by the method of the present invention and to their use.

Manufacturing three-dimensional scaffolds using cryogenic prototyping

A vascular prosthesis is adapted for use as an access graft having a permanent set, kink-resistant U-bend section. A method for making the access graft includes the utilization of a tube of implantable material adapted to be attached in a blood circulatory system and to provide thereby a site for access for cannulation, the tube having a permanent set, kink-resistant U-shaped bent section and the method including the steps of forming a straight tube by a process which yields a set, dryable tube; taking a length of the tube and inserting in it along its length a flexible rod-like support member; wrapping the tube containing the support member around a core so as to define a bend in the tube, the bend being wet at this stage; drying the wet tube containing the support member while wrapped around the core to permanently shape the tube into a bent form; removing the dried tube from the core and removing the support member so as to form an access graft, U-shaped bent section.

Method of making an access graft and a vascular prosthesis

A vascular prosthesis is formed from a luminate vessel by precipitating onto the vessel a sheet of polymer from a solution including an organic solvent and precipitable polymer, and forming an aperture in the sheet, the aperture communicating with the lumen of the vessel.

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Singapore, Singapore

Kerm Sin Chian