Gilead Sciences, Inc.

Merck Sharp + Dohme Corp.

Modernatx, Inc.

Msd R&d Co., Ltd.

Kerim Babaoglu

Michael L Mitchell

Lianhong Xu

Paul A Roethle

Ryan McFadden

Hong Yang

Hongtao Liu

Hai Yang

David Sperandio

John O Link

Richard L Mackman

Dustin S Siegel

Hon Chung Hui

Jay P Parrish

Hongyan Guo

Oliver L Saunders

Michael Sangi

Constantine G Boojamra

Yingmei Qi

Eugene J Eisenberg

Randall Halcomb

Gediminas J Brizgys

Randall W Vivian

Paul Hrvatin

Kyla Bjornson

James G Taylor

Eric Lansdon

Mark E Fraley

Giuseppe Ciaramella

Paul J Coleman

Elizabeth M Bacon

Craig A Stump

Casey Cameron McComas

John S Wai

Jianming Bao

Richard Y Huang

Ping Liu

Robert H Jiang

Britton Kenneth Corkey

Chun Sing Li

Harold B Wood

Helen J Mitchell

Jianyu Sun

Dongfang Meng

Lan Zhang

Eric Yi-Chun Huang

Mark W Embrey

Xiaowu Chen

Yi-Heng Chen

Andrew John Cooke

Xiaochun Han

Abbas M Walji

Qinghua Mao

James D Trenkle

Melody McWherter

Swati P Mercer

Xu-Fang Zhang

Zhiqi Qi

Jane Yang Wu

Kathy Schirripa

David C Nickle

Jessica Anne Flynn

Jake Cha

James Taylor

Casey C Mccomas

Melody Mcwherter

Andrew J Cooke

Randall L Halcomb

Paul Roethle

Elizabeth Bacon

The disclosure relates to broad spectrum influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccine. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.

Broad spectrum influenza virus vaccine

The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Pyrazolo[1,5-A]pyrimidines for antiviral treatment

The present invention relates to Fused Tricyclic Heterocycle Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, X, Y, m, R1, R5, Ra and Rb are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocycle Derivative, and methods of using the Fused Tricyclic Heterocycle Derivatives for treating or preventing HIV infection in a subject. 

Fused tricyclic heterocyclic compounds as HIV integrase inhibitors

The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula I.

Therapeutic compounds

The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA. 

TrkA kinase inhibitors, compositions and methods thereof

The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.

2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS

The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I). 

2-quinolinyl-acetic acid derivatives as HIV antiviral compounds

Naphthalene acetic acid derivatives against HIV infection

This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula I wherein R, R, R, R, R, W, X, and Z are as described herein.

Quinoline derivatives as bromodomain inhibitors

The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I). 

Naphth-2-ylacetic acid derivatives to treat AIDS

Compounds of formula I': or salts thereof are provided. Pharmaceutical compositions comprising a compound of formula I&#x2032;, processes for preparing compounds of formula I&#x2032;, intermediates useful for preparing compounds of formula I&#x2032; and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal are also provided.

The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula I. 

Benzothiazole compounds and their pharmaceutical use

Compounds disclosed herein including compounds of formula I': and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.

Growing community of inventors

Lansdale, PA, United States of America

Kerim Babaoglu