Scynexis, Inc.

Avista Pharma Solutions, Inc.

Keqiang Li

Jason Daniel Speake

Joe B Perales

Cyprian Okwara Ogbu

Michael Robert Peel

David Renwick Houck

Jeffrey A Adams

Brian H Heasley

Andrew Scribner

Joseph Alexander Moore, Iii

Ahmed Mamai

Bharathi Pandi

Kurt S Van Horn

Bakela Nare

Cisco Bee

The present invention relates to single enantiomer isothiazoline compounds of formula (I): and methods of synthesizing the compounds. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to veterinary compositions comprising said compounds.

Single enantiomer antiparasitic compounds

The present disclosure describes a synthetic process and novel intermediates related to spirocyclic azetidenyl-isobenzofuran derivatives having an isothiazoline moiety, which are useful as antiparasitics.

Synthetic process and intermediates

Disclosed are cyclosporine derivatives in which the 3-Sarcosine carbon and 5-Valine nitrogen are each substituted by a non-hydrogen substituent, and their use as pharmaceuticals, in particular for the treatment of hepatitis C virus.

Macrocyclic peptides

Disclosed herein are compounds of general formula (I): wherein A, B, Rand Rare as defined in the specification, and their use as pharmaceuticals.

Macrocycles

This invention provides compounds of general formula (I): wherein A, B, R, Rand X are as defined in the specification, and pharmaceutical compositions prepared from the same, for use in treatment of hepatitis C virus and/or human immunodeficiency virus.

Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection

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Cary, NC, United States of America

Keqiang Li