The University of Tokyo

Microbial Chemistry Research Foundation

Savid Therapeutics Inc.

Kenzo Yamatsugu

Motomu Kanai

Masakatsu Shibasaki

Akira Sugiyama

Tatsuhiko Kodama

Hiroki Suto

Kazuki Takahashi

Hitoshi Kurumizaka

Masanobu Tsukagoshi

Shigehiro Kawashima

Junji Nishigaki

Takefumi Yamashita

Toshifumi Tatsumi

Yuzo Toda

Shin Kamijo

Ikuo Fujimori

Yasuhiro Arimura

Akihisa Osakabe

Nozomu Nagashima

Yuki Aoi

Yoshifumi Amamoto

Kana Tanabe

Haiyan Zhu

Tadashi Ishiguro

Jiaan Liu

[Object] It is an object of the present invention to provide a conjugate of a biotin-modified dimer and a phthalocyanine dye, which is used in photoimmunotherapy. [Means for Solution] A compound represented by the following formula (1) or a salt thereof:

Conjugate of biotin-modified dimer and phthalocyanine dye

An artificial catalyst system which can acylate chromosome proteins with high selectivity has successfully been established by using a combination of an acyl CoA activating catalyst having target acylation area binding ability and acyl CoA or a derivative thereof.

Artificial catalyst system for selective acylation of chromosome protein

A compound represented by the following general formula (1), and a method for producing the compound represented by the general formula (1), the method comprising: reacting together a compound represented by the following general formula (2), a compound represented by the following general formula (3), and a compound represented by the following general formula (4): 

Compound, method for producing the same, and method for producing oseltamivir phosphate

Disclosed is a novel asymmetric ligand which can be synthesized by a short process at low cost and is capable of exhibiting higher catalytic activity and enantioselectivity than the conventional ligands derived from sugars. Also disclosed are a method for producing such an asymmetric ligand, and a catalyst using such an asymmetric ligand. Specifically disclosed is a ligand represented by the general formula I below or the like. (In the formula, Rand Rindependently represent 0-5 substituents; X represents P, As or N; m represents an integer of 0-7; n represents an integer of 0-3; A-Aindependently represent hydrogen, fluorine, chlorine, bromine, benzoyl or acetyl, or alternatively Aand Acombine together to form a ring.) 

Ligand, method for producing the same, and catalyst using the ligand

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Tokyo, Japan

Kenzo Yamatsugu