Kuraray Co., Ltd.

Taiho Pharmaceutical Company Limited

Yoshitomi Pharmaceutical Industries, Ltd.

Kenzo Arizono

Michio Terasawa

Takashi Nishida

Yutaka Mizushima

Koichi Kanehira

Rie Igarashi

Noriyuki Yamamoto

Hirofusa Ajioka

Masahito Komuro

Masayuki Inoue

Keiko Hoshi

Manzo Shiono

Michiharu Nobutoki

11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof. 11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.

11-beta, 17-alpha, 21-trihydroxy-1, 4-pregnadiene-3, 20 21-[(E-E)-3,7,

11.beta., 17.alpha.,21-trihydroxy-1,4-pregnadiene-3,20-dione

An antiinflammatory and analgesic gelled ointment contains pranoprofen, at least one member selected from the group consisting of lower aliphatic alcohol, polyethylene glycol, methyl ethyl ketone and acetone, a gelling agent selected from the group consisting of carboxyvinyl polymer, hydroxyethyl cellulose, alginic acid and carboxymethyl cellulose, a water-soluble basic substance selected from the group consisting of ammonia, sodium hydroxide, potassium hydroxide, triethanolamine, diethanolamine, diisopropanolamine, triisopropanolamine and triethylamine, and water.

Pranoprofen gelled ointment

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Nakatsu, Japan

Kenzo Arizono