Teikoku Hormone Mfg. Co., Ltd.

Kenyu Shibata

Naoyuki Koizumi

Shigehiro Takegawa

Mamoru Mieda

Kotaro Gotanda

Tsutomu Ishimori

Toshimi Seki

Kikuo Yasuda

Nobuyoshi Minami

Shigeki Iwashita

Katsuhiko Miyasaka

Tomoko Kawachi

Hiroo Takahashi

Seijiro Honma

Masafumi Shiraiwa

Takako Sasaki

Tomio Nakao

Nobuaki Yamakoshi

Teruaki Matsui

Eiichiro Shimazawa

Akihiro Izumi

Takeshi Masuda

Toshihisa Itaya

Kohichi Hasumi

Masako Uno

Tomoyuki Saito

Fumiko Inoue

Kaoru Ueda

Koichi Minato

Mitsuteru Numazawa

Masaaki Tarutani

Kunihiro Konishi

Shigeru Kurata

Hideki Sakuma

7-substituted oxa- or azasteroid compound

Oxa- or azasteroid derivatives

Benzothiophene derivative

A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an assymmetric carbon atom, or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.

Pyridazinone derivatives

Carbostyril substituted pyridazinones

A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an asymmetric carbon atom, or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.

A compound represented by the following formula ##STR1## wherein A represents a hydrogen atom or a lower alkanoyl group, Z represents an oxygen atom or the group ##STR2## in which R represents a hydrogen atom or a lower alkyl group, and X represents a halogen atom, the compound being useful for controlling androgen-dependent diseases, particularly for preventing abortion or for contraception.

Compositions and methods employing 2-oxa- or -aza-pregnan compounds for

A pyridazinone derivative represented by the following general formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, either one of R.sub.2, R.sub.3 and R.sub.4 represents a hydrogen atom and the remaining two of them represent a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and a salt thereof. The compounds are useful as antihypertensive agents.

Antihypertensive pyridazinone aminoisopropanol derivatives

A compound represented by the following formula ##STR1## wherein A represents a hydrogen atom or a lower alkanoyl group, Z represents an oxygen atom or the group ##STR2## in which R represents a hydrogen atom or a lower alkyl group, and X represents a halogen atom, the compound being useful for controlling androgen-dependent diseases, particularly for preventing prostatic hypertrophy.

2-oxa- or -aza-pregnane compounds

Phenoxypropylamine derivatives of the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl or ethyl group, R.sub.2 and R.sub.3, independently from each other, represent a lower alkyl group, or together form a linear alkylene group having 4 to 7 carbon atoms which may be optionally substituted by a hydroxyl or hydroxymethyl group, and R.sub.4 represents a hydrogen atom or a group of the formula --R.sub.5 --Z in which R.sub.5 represents a lower alkylene group, and Z represents a hydrogen atom or an amino, mono- or di-(lower alkyl)-amino, hydrdoxy lower alkylamino, lower alkanoylamino, hydroxyl, lower alkoxy, lower alkanoyloxy, phenoxy, halophenoxy, benzoyloxy or halobenzoyloxy group, and the salts thereof; to a process for production thereof; and to their medicinal use, particularly to antiulcer agents comprising these phenoxypropylamine derivatives or their salts.

Antiulcer phenoxypropylamine derivatives

Growing community of inventors

Inagi, Japan

Kenyu Shibata