Pds Biotechnology Corporation

Kenya N Toney Johnson

Leaf Huang

Frank Bedu-Addo

Gregory Conn

Elizabeth Ann Vasievich

Weihsu Claire Chen

Weihsu Chen

A composition and method for activating immune cells ex-vivo, or inducing an immune response in a subject including a composition comprising at least one chiral cationic lipid. The chiral cationic lipid in one embodiment comprises a nonsteroidal cationic lipid having a structure represented by formula (I); wherein in Ris a quaternary ammonium group, Yis a space chosen from a hydrocarbon chain, an ester, a ketone, and a peptide, C* is a chiral carbon, Rand Rare independently chosen from a saturated fatty acid, an unsaturated fatty acid, an ester-linked hydrocarbon, phosphor-diesters, and combination thereof.

Stimulation of an immune response by enantiomers of cationic lipids

A composition and method for activating immune cells ex-vivo, or inducing an immune response in a subject including a composition comprising at least one chiral cationic lipid. The chiral cationic lipid in one embodiment comprises a nonsteroidal cationic lipid having a structure represented by formula (I); wherein in Ris a quaternary ammonium group, Yis a spacer chosen from a hydrocarbon chain, an ester, a ketone, and a peptide, C* is a chiral carbon, Rand Rare independently chosen from a saturated fatty acid, an unsaturated fatty acid, an ester-linked hydrocarbon, phosphor-diesters, and combinations thereof.

Compositions and methods for treating immune cells and activating immune responses are disclosed. The compositions comprise one or more optically active chiral cationic lipids.

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Mason, OH, United States of America

Kenya N Toney Johnson