Pds Biotechnology Corporation

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Mkrtichyan, Mikayel

Khleif, Samir N.

Kenya Johnson

Frank Bedu-Addo

Eric Jacobson

Samir N Khleif

Mikayel Mkrtichyan

Leaf Huang

Weihsu Chen

Weili Yan

Gregory Conn

Carol Mercer

The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one therapeutic factor. The disclosure also provides methods of reducing an immune suppressor cell population in a mammal, methods of argumenting an immune response in a mammal, and methods of treating a diseases in a mammal utilizing the vaccine compositions.

Methods of modulating immune responses with cationic lipid vaccine compositions

The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.

Stimulation of an immune response by cationic lipids

The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one antigen, wherein the adjuvant is a cationic lipid. The disclosure also provides methods of treating a disease in a mammal, methods of preventing a disease in a mammal, and methods of effecting antigen cross presentation to induce a humoral immune response and a cellular immune response in a mammal utilizing the vaccine compositions. Cross presentation of various antigens can be achieved by formulating the specific antigens with cationic lipids possessing adjuvant properties.

Vaccine compositions and methods of use

Method for reducing a myeloid derived suppressor cell population with cationic lipid vaccine compositions

The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one therapeutic factor. The disclosure also provides methods of reducing an immune suppressor cell population in a mammal, methods of augmenting an immune response in a mammal, and methods of treating a disease in a mammal utilizing the vaccine compositions.

Cationic lipid vaccine compositions and methods of use

Growing community of inventors

Mason, OH, United States of America

Kenya Johnson