Takasago International Corporation

The Mennen Company

Mandom Corporation

Kenya Ishida

Takashi Aida

Kenji Yagi

Kazutoshi Sakurai

Shigeru Tanaka

Hiroyuki Matsuda

Hideo Ujihara

Kazuma Hojo

Tetsuya Yamamoto

Kiyohito Sawano

Toshimitsu Hagiwara

Carter B Green

Kenji Maruyama

Hideki Nara

Toshiya Sato

Kenichiro Shiroyama

Yasuhiro Komatsuki

Michael E Lankin

Tetsuro Yamasaki

Morton L Barr

Louis J Lombardo

Augustinus G Van Loveren

Teruhiko Inaba

Akira Amano

Tetsuo Nakatsu

Taichiro Touge

Miharu Ogura

Eiko Tamai

Robert Suffis

Amrit S Mankoo

Hamako Hata

Toshiya Sato, Deceased

Kazushi Mashima

Yuichiro Yamazaki

Hideaki Ohta

Makoto Harada

Kazuhiko Tokoro

Hironori Maeda

Hisao Iwai

Raphael K Kang

Takashi Ohshima

Jennifer B Tartaglia

Fumitaka Fujita

Akemi Shimada

Takashi Nishida

Gary A Reitz

Hironori Shimizu

Fumihiro Yanaka

Satomi Kunieda

Izumi Kawada

Takanori Iwasaki

Kenji Arata

Masayuki Takaishi

Shu Sakuyama

Chiyomi Birou

Satoko Tsukada

Jennifer B Mei

Tomoko Yamamoto

This TRPA1 activity inhibitor contains a compound represented by formula (I) wherein R, R, Rand Reach independently represent a hydrogen atom or a methyl group, and R, R, Rand Reach independently represent a hydrogen atom, a methyl group or &#x2014;O&#x2014;R&#x2014;OH (in the formula, Rrepresents an alkylene group optionally having a substituent group), provided that at least one group of R, R, Rand Ris &#x2014;O&#x2014;R&#x2014;OH. 

TRPA1 activity inhibitor

An object of the present invention is to provide a method for producing an ether compound easily in a small number of steps at lower costs in high yields. The present invention relates to a method in which the ether compound represented by the general formula (1) is produced by reacting the specific carbonyl compound specified in the general formula (2) and the specific dialkoxy compound specified in the general formula (3) with hydrogen in the presence of a hydrogenation catalyst and an acidic substance to perform hydrogenation. 

Method for producing ether compound

The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E,6E,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E,6Z,8Z)&#x2014;N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided. Synthetic spilanthol flavor compositions can be added to orally consumed products, such as, but not limited to, foods, beverages, pharmaceuticals, nutraceuticals, or therapeutic compositions, oral personal care products, gums (e.g. chewing gum or bubble gum), candy or lozenges.

Synthetic spilanthol and use thereof

The present invention provides a method for producing a nitrile represented by general formula (1) (in the formula, R denotes an optionally substituted alkyl group, alkenyl group, dienyl group, aralkyl group or aryl group having a total of 3-20 carbon atoms), and the method includes heating an aldoxime represented by general formula (2) (in the formula, R denotes the same groups as those mentioned above) at 80-250&#xb0; C. in the presence of an alkali metal or alkaline earth metal salt of phosphoric acid (catalyst A) and distilling off water generated as the reaction progresses to outside the reaction system.

Method for producing nitrile

The present invention provides a novel macrocyclic compound exhibiting superior odor qualities and having a musk-like aroma, a method for producing the same, and a novel flavor or fragrance composition, and food products or beverages, fragrances or cosmetics, daily necessities or household goods and oral products using the novel macrocyclic compound. The invention relates to a compound represented by the formula (1), wherein each of wavy lines represents at least one of an E-configuration of C&#x2550;C double bond and an Z-configuration of C&#x2550;C double bond; m represents an integer of 0 to 10; and n represents an integer of 1 to 11, and n represents an integer of 1 to 11 when m is 0 to 4 or 6 to 10, and n is an integer of 1 or 3 to 11 when m is 5. 

Macrocyclic triene lactones having unconjugated triene structure, its production method and its synthetic intermediate

Provided is a method for producing an optically active ceramide by an N-acylation (amidation) reaction of an optically active aminodiol, wherein a crude ceramide produced therein is purified by an industrially advantageous process. Namely, provided is a method for producing a high-purity ceramide that has high diastereo purity with high yield. A high-purity ceramide is produced by: a step wherein a ceramide represented by general formula (1) is produced by reacting an aminodiol with an alkyl ester having 1-5 carbon atoms of an aliphatic carboxylic acid having 12-24 carbon atoms, said aliphatic carboxylic acid optionally having a hydroxyl group, in a hydrocarbon solvent having 5-10 carbon atoms; and a step wherein an alcohol having 1-3 carbon atoms is added into the reaction mixture obtained in the preceding step, thereby causing crystals to precipitate. (In the formula, Rrepresents an alkyl group which has 13-17 carbon atoms and optionally has a carbon-carbon unsaturated bond; Rrepresents an alkyl group which has 11-23 carbon atoms and optionally has a hydroxyl group; and * represents an optically active state.).

Method for producing high-purity ceramide

Provided is an amide ester that is useful as an intermediate manufacturing product for an aroma compound such as spilanthol or the like. Also provided is a spilanthol manufacturing method using said amide ester. High-purity spilanthol can be manufactured by reacting an amide ester represented by general formula (1) with a basic compound. (In the formula, Rrepresents a C1-6 alkyl group or a phenyl group that may be substituted with a Calkyl group, a Calkoxy group, or a halogen atom; Rrepresents a Chydrocarbon group; and the wavy lines represent cis configurations, trans configurations, or a mixture of the two configurations.)

Method for manufacturing spilanthol and intermediate manufacturing product therefor

Disclosed is a cooling component or sensate component which does not have undesirable stimulus feeling, bitterness and the like and is excellent in the persistence of refresh-feeling and cool-feeling, a sensate composition which comprises the same, and various products that comprise said sensate composition. Also disclosed is a cooling agent comprising (3S)-1-menthyl 3-hydroxybutyrate represented by the following formula (I) 

Process for producing (3S)-1-menthyl 3-hydroxybutyrate and sensate composition

Bioavailability of a ceramide, which is a minimally soluble material of a skin care composition exhibiting an excellent effect is enhanced by combining at least one component selected from ceramides represented by Formula (1): and at least one component selected from aliphatic alcohol having 12 to 30 carbon atoms.

Lipid composition and skin care formulation containing the same

It is to provide a technique for preventing aggregation or caking of menthol at the time of its keeping. In addition, it is to provide a lipid composition, which can show excellent thermal stability even in the case of high temperature at the time of keeping menthol and at the time of blending in a product, does not cause mutual aggregation of powders, particles, flakes, pellets, sticks and the like of menthol, and can maintain its shape retention property. From 10 to 50% by mass of sterols are added to and mixed with from 50 to 90% by mass of menthol, and the resultant is melted with heating. Paraffins may be further added and mixed in an amount of 20% by mass or less, based on the lipid composition.

Lipid composition having excellent shape retention property and product

The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E,6E,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E,6Z,8Z)-N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided. Synthetic spilanthol flavor compositions can be added to orally consumed products, such as, but not limited to, foods, beverages, pharmaceuticals, nutraceuticals, or therapeutic compositions, oral personal care products, gums (e.g. chewing gum or bubble gum), candy or lozenges.

The invention relates to a sensory stimulant composition containing one or more of vanillin acetals represented by the general formula (1), and a flavor and fragrance composition, a beverage or food product, a fragrance or cosmetic product, a daily utensil product, an oral composition, or a pharmaceutical product containing the sensory stimulant composition with a warming sensation agent or cooling sensation substance, if necessary. Vanillin acetals represented by the general formula (1) show an excellent pungent and/or warming sensation effect and a cooling sensation-emphasizing effect.

Vanillin acetals and sensory stimulant composition containing the same

A cooling sensation agent composition with a prolonged cool sensation effect is provided comprising at least one compound selected from the group consisting of aceia or ketal derivatives of 3-(1-menthoxy)propan-1,2-diol represented by Formula (1), single or mixed carbonic esters ol one or two kinds ol alcohols represented by Formula (2), and carboxylic esters represented by Formula (4). A sensory stimulation agoni composition, a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent; and new compounds are also provided.

Cooling sensation agent composition and sensory stimulation agent composition

Disclosed is a method for producing (3S)-l-menthyl 3-hydroxybutyrate of the following formula (I) by subjecting l-menthyl acetoacetate to asymmetric hydrogenation. The compound may be used as a cooling component or sensate component which does not have undesirable stimulus feeling, bitterness and the like and is excellent in the persistence of refresh-feeling and cool-feeling. 

Process for producing (3S)-I-menthyl 3-hydroxybutyrate and sensate composition

The present invention provides a method for producing sulfur-containing carboxylic acid esters that are useful for aromatizing and flavoring purpose and can cater to the needs for diversified aromatized and/or flavored products, and to further provide a fragrance and/or flavor composition comprising the ester producible by the method and an aromatized and/or flavored product comprising the same. The sulfur-containing carboxylic acid ester is represented by the following formula (3): wherein Rrepresents an alkyl group having 1 to 10 carbon atoms or an optionally substituted phenyl group (wherein the substituent thereof is an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms), Rand Rindependently represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms or an alkenyl group having 2 to 10 carbon atoms, or Rand Rtogether form an alkylene group, and Rrepresents an alkyl group having 1 to 4 carbon atoms.

Method for producing sulfur-containing carboxylic acid esters

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Kanagawa, Japan

Kenya Ishida